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Mutations in the Mitochondrial Methionyl-tRNA Synthetase Cause a Neurodegenerative Phenotype in Flies and a Recessive Ataxia (ARSAL) in Humans
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
An increasing number of genes required for mitochondrial biogenesis, dynamics, or function have been found to be mutated in metabolic disorders and neurological diseases such as Leigh Syndrome. In a forward genetic screen ...
Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
(ClinMed International Library, 2015-08)
The retinal pigment epithelium (RPE) is essential for the integrity and function of the retina. RPE cells exert key functions to maintain photoreceptors´ (PRs) viability and functionality, such as light absorption and ...
The Time Keeping System: a key organizational element
(World Scientific, 2017)
Life has evolved in a cyclic environment, and consequently, during evolution the time dimension was incorporated in the inner organization of every single biological structure. This incorporation is evident in the biological ...
Uncovering Photolyase/Cryptochrome Genes Diversity in Aquatic Microbiomes Exposed to Diverse UV-B Regimes
(Inter-Research, 2020-09)
During evolution, microorganisms exposed to high UV-B doses developed a fine-tuned photo-enzymes called ?photolyases? to cope with DNA damage by UV-B. These photoreceptors belonging to the Cryptochrome/Photolyase Family ...
Uncovering Photolyase/Cryptochrome Genes Diversity in Aquatic Microbiomes Exposed to Diverse UV-B Regimes
(Inter-Research, 2020-09)
During evolution, microorganisms exposed to high UV-B doses developed a fine-tuned photo-enzymes called "photolyases" to cope with DNA damage by UV-B. These photoreceptors belonging to the Cryptochrome/Photolyase Family ...
Avaliação da migração e integração de células-tronco mesenquimais ao tecido retiniano lesado: estudo experimental em ratos Wistar
(Universidade Federal de Minas GeraisUFMG, 2009-07-03)
PURPOSE: To evaluate the migration, retinal integration and differentiation of bone marrowmesenchymal stem cells (BM-MSCs) injected into the vitreous cavity of rat eyes with retinal injury. METHODS: Adult rat retinas were ...
Avaliação da migração e integração de células-tronco mesenquimais ao tecido retiniano lesado.: Estudo experimental em ratos Wistar
(Universidade Federal de Minas GeraisUFMG, 2009-07-03)
PURPOSE: To evaluate the migration, retinal integration and differentiation of bone marrowmesenchymal stem cells (BM-MSCs) injected into the vitreous cavity of rat eyes with retinal injury. METHODS: Adult rat retinas were ...