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Targeted therapy to annihilate the immune-evading phenotype in cancer evolution
(Informa Healthcare, 2018-07)
Cancer is a moving target, and targeted therapy must ultimatelydeal with the evolution of the disease. This is becauseevolution is the substrate for development of resistance totargeted therapy. A successful therapeutic ...
XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy
(Taylor and Francis Inc., 2009)
Endoplasmic reticulum (ER) stress has been extensively described in many protein misfolding disorders including amyotrophic lateral sclerosis (ALS). Adaptation to ER stress is mediated by the activation of an integrated ...
Assinaturas de miRNAs envolvidos na malignidade, EMT e metástase revelam o papel do miR-322-5p na plasticidade fenotípica do melanoma
(Universidade Federal de São Paulo, 2022-11-23)
A compreensão das bases moleculares do melanoma é crucial para o desenvolvimento de novos alvos terapêuticos e identificação de biomarcadores. Entre as alterações moleculares observadas estão aquelas que ocorrem na classe ...
An outside-in switch in integrin signaling caused by chemical and mechanical signals in reactive astrocytes
(Frontiers Media, 2021)
Astrocyte reactivity is associated with poor repair capacity after injury to the brain, where chemical and physical changes occur in the damaged zone. Astrocyte surface proteins, such as integrins, are upregulated, and the ...
TonEBP suppresses IL-10-mediated immunomodulation
(Nature, 2016)
TonEBP is a key transcriptional activator of M1 phenotype in macrophage, and its high expression is associated with many inflammatory diseases. During the progression of the inflammatory responses, the M1 to M2 phenotypic ...
Divergence in plant traits and increased modularity underlie repeated transitions between low and high elevations in the Andean Genus Leucheria
(Frontiers Media, 2020)
Understanding why some plant lineages move from one climatic region to another is a mayor goal of evolutionary biology. In the southern Andes plant lineages that have migrated along mountain ranges tracking cold-humid ...
Phenotypic plasticity in clutch size regulation among populations of a potential invasive fruit fly from environments that vary in host heterogeneity and isolation
(Cambridge University Press, 2018-05)
Phenotypic plasticity is thought to evolve in response to environmental unpredictability and can shield genotypes from selection. However, selection can also act on plastic traits. Egg-laying behaviour, including clutch ...
Endometrial transcriptional profiling of a bovine fertility model by Next-Generation Sequencing
(Elsevier B.V., 2016-03-01)
Studying the multitude of molecular networks and pathways that are potentially involved in a complex trait such as fertility requires an equally complex and broad strategy. Here, we used Next-Generation Sequencing for the ...
T-lymphocyte phenotype and function triggered by Aggregatibacter actinomycetemcomitans is serotype-dependent
(Blackwell Munksgaard, 2015)
& Sons Ltd. Background and Objective: Based on lipopolysaccharide (LPS) antigenicity, different Aggregatibacter actinomycetemcomitans serotypes have been described. Serotype b strains have demonstrated a stronger capacity ...
KRAS gene mutations in Noonan syndrome familial cases cluster in the vicinity of the switch II region of the G-domain: Report of another family with metopic craniosynostosis
(WILEY-BLACKWELLMALDEN, 2012)
Noonan syndrome (NS) and Noonan-related disorders [cardio-facio-cutaneous (CFC), Costello, Noonan syndrome with multiple lentigines (NS-ML), and neurofibromatosis-Noonan syndromes (NFNS)] are a group of developmental ...