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Modulatory effects of acidic ph and membrane potential on the adsorption of ph-sensitive peptides to anionic lipid membrane
(2021-05-01)
Anionic lipid membrane electrostatic potential and solution pH can influence cationic peptide adsorption to these bilayers, especially those containing simultaneously acid and basic residues. Here, we investigate the effects ...
Labaditin, a cyclic peptide with rich biotechnological potential: preliminary toxicological studies and structural changes in water and lipid membrane environment
(Springer, 2011-01-01)
Cyclic peptides isolated from the plants of the Euphorbiaceae family have been largely studied due to their rigid conformation, which is considered significant for biologic activity. The peptide Labaditin (L(0)) and its ...
Contribution of the tyr-1 in plantaricin149a to disrupt phospholipid model membranes
(MDPI AGBasel, 2013-06)
Plantaricin149a (Pln149a) is a cationic antimicrobial peptide, which was suggested to cause membrane destabilization via the carpet mechanism. The mode of action proposed to this antimicrobial peptide describes the induction ...
Acetylcholinesterase inhibitory activity of a naturally occurring peptide isolated from Boana pulchella (Anura: Hylidae) and its analogs
(Springer, 2020-03)
Alzheimer’s disease (AD), the most common form of dementia, is a growing problem worldwide, with 10 million incident cases registered every year. The complex etiology of AD has not been clarified yet and represents an ...
The Importance of Ring Size and Position for the Antiplasmodial Activity of Angiotensin II Restricted Analogs
(Springer, 2014-09-01)
Malaria is caused by the protozoa Plasmodium and is responsible for approximately one million deaths annually. the antimalarial effects of angiotensin II and its analogs against Plasmodium gallinaceum and falciparum have ...
Isolation and sequence analysis of peptides from the venom of Protonectarina sylveirae (hymenoptera‐vespidae)
(1993-01-01)
Three new venom peptides were isolated from the Brazilian wasp; Protonectarina sylveirae and their complete amino acid sequences were determined by Edman degradation as well as by FAB‐mass spectrometry. One (P‐8) of them ...
Functional and Topological Studies with Trp-Containing Analogs of the Peptide StII(1-30) Derived From the N-Terminus of the Pore Forming Toxin Sticholysin II: Contribution to Understand its Orientation in Membrane
(Wiley-Blackwell, 2013-07-01)
Sticholysin II (St II) is the most potent cytolysin produced by the sea anemone Stichodactyla helianthus, exerting hemolytic activity via pore formation in membranes. The toxin's N-terminus contains an amphipathic alpha-helix ...
Insight into the effect of the vasopressin analog desmopressin on lung colonization by mammary carcinoma cells in BALB/c mice
(Int Inst Anticancer Research, 2014-07)
Background/Aim: Desmopressin (dDAVP) is a synthetic peptide analog of vasopressin with antidiuretic and hemostatic properties. Recent experimental evidence suggested that dDAVP can inhibit metastasis formation by agonist ...
Investigação in silico da interação de peptídeos antimicrobianos análogos da Stigmurina com modelos de membranas
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA, 2021-09-23)
Stigmurin (Stig), a peptide originating from the venom of the scorpion Tityus Stigmurus,
and its analogs (StigA8 and StigA18), are effective in previous in-vitro and in-vivo studies
(Larvae of Mariposa Galleria Mellonella). ...