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The multifunctional Ca2 +/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements
(Elsevier, 2013-01)
Titin-based passive stiffness is post-translationally regulated by several kinases that phosphorylate specific spring elements located within titin's elastic I-band region. Whether titin is phosphorylated by calcium/calmodulin ...
Drug transport mechanisms in helminth parasites: Passive diffusion of benzimidazole anthelmintics
(Academic Press Inc Elsevier Science, 2006-05)
Anthelmintic molecules must reach their receptors inside target parasites to exert the pharmacological eVect. Available data suggest that the main route of entry of antiparasitic drugs into helminth parasites would be ...
Current state and future prospects of immunotherapy for glioma
(Future Medicine, 2018-03)
There is a large unmet need for effective therapeutic approaches for glioma, the most malignant brain tumor. Clinical and preclinical studies have enormously expanded our knowledge about the molecular aspects of this deadly ...
Current state and future perspectives in QSAR models to predict blood-brain barrier penetration in central nervous system drug R&D
(Bentham Science Publishers, 2017-02)
The Blood-Brain Barrier (BBB) is a physical and biochemical barrier that restricts the entry of certain drugs to the Central Nervous System (CNS), while allowing the passage of others. The ability to predict the permeability ...
Human exposure to polycyclic aromatic hydrocarbons in the atmosphere of an agricultural area of central Chile and inhalation cancer risk assessments
(2023)
Polycyclic aromatic hydrocarbons (PAHs) are persistent toxic substances prone to long-range atmospheric transport. Even in low concentrations, environmental exposure to PAHs can impact human health. In this study we aimed ...
Implementing a Quadrature NMR Spectrometer based on a passive RC splitter-combiner networkImplementación de un espectrómetro NMR en cuadratura basado en una red RC pasiva splitter-combiner
(USFQ PRESS, departamento editorial de la Universidad San Francisco de Quito USFQ, 2011)
Speaking common mistakes in students of target language II at LEI: a case study
(2019-04)
“People who know and perform a language are referred as ´speakers´ of that language. Due to speaking included all other kinds of knowledge, so most language learners are mainly interested in learning to communicate orally. ...
GAPS-megacities: A new global platform for investigating persistent organic pollutants and chemicals of emerging concern in urban air
(Elsevier, 2020-12)
A pilot study was initiated in 2018 under the Global Atmospheric Passive Sampling (GAPS) Network named GAPS-Megacities. This study included 20 megacities/major cities across the globe with the goal of better understanding ...
Oscillation of the velvet worm slime jet by passive hydrodynamic instability
(Nature Communications, 2015-03-17)
The rapid squirt of a proteinaceous slime jet endows velvet worms (Onychophora) with a unique mechanism for defence from predators and for capturing prey by entangling them in a disordered web that immobilizes their target. ...