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mu/delta Cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat
(Blackwell Publishing LtdOxfordInglaterra, 2002)
NMDA antagonist MK 801 in nucleus accumbens core but not shell disrupts the restraint stress-induced reinstatement of extinguished cocaine-conditioned place preference in rats
(Elsevier Science, 2016-12)
Relapse is a common feature of cocaine addiction. In rodents, it can be elicited by cues, stress or the drug. Restraint stress-induced reinstatement of cocaine-conditioned place preference (CPP) is a useful model to study ...
Effects of single injection of naloxone and damgo within nucleus accumbens septi in the plus maze test in rats
(Polskiego Towarzystwa Farmaceutycznego, 2018-01)
Nucleus accumbens septi (NAS) is studied because its relations with cognition and anxiety. Its pharmacological manipulation is widely used in experimental psychopathology to reproduce psychotic signs and symptoms in animal ...
AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task
(Pergamon-Elsevier Science Ltd, 2002-06)
The effect of the blockade of N-methyl-D-aspartic acid (NMDA)-type glutamatergic receptors in the nucleus accumbens septi (Acc) during different phases of a passive avoidance task (step-through paradigm, two chambers) of ...
The functional role of ascending nociceptive control in defensive behavior
(ELSEVIER SCIENCE BVAMSTERDAM, 2013-08-02)
Ascending nociceptive control is a novel spino-striato-rostral ventral medulla pain modulation pathway that mediates heterosegmental pain-induced analgesia, i.e., noxious stimulus-induced antinociception. In this study, ...
Exogenous GM1 ganglioside increases accumbal BDNF levels in rats
(Elsevier Science, 2015-02)
Gangliosides are compounds that are abundant throughout the CNS, participating actively in neuroplasticity. We previously described that exogenous GM1 ganglioside pretreatment enhances the rewarding properties of cocaine, ...
Effects of Ethanol Exposure During Adolescence or Adulthood on Locomotor Sensitization and Dopamine Levels in the Reward System
(Frontiers Media Sa, 2020-03-06)
Behavioral sensitization is a process of neuroadaptation characterized by a gradual increase in motor behaviors. The major neural substrates involved in the behavioral sensitization lie on the dopaminergic mesocorticolimbic ...
Susceptibility to extinction and reinstatement of ethanol-induced conditioned place preference is related to differences in astrocyte cystine-glutamate antiporter content
(2020-01-01)
Individual susceptibility to alcohol effects plays an important role in the development of alcohol addiction and studies have shown that glutamate release is altered after chronic ethanol consumption. The cystine-glutamate ...
N-acetylcysteine treatment blocks the development of ethanol-induced behavioural sensitization and related ΔFosB alterations
(2016-11-01)
Ethanol addiction is a serious public health problem that still needs more effective pharmacological treatment. A key factor in the development and maintenance of this disease is the advent of neuroadaptations in the ...
Histaminergic systems of the limbic complex on learning and motivation
(Elsevier Science, 2001-10)
The possible role of histamine sensitive sites in hippocampus and the nucleus accumbens on memory and exploratory motivation was studied. As a model of memory, the learning of an active avoidance response to an ultrasonic ...