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Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning
(2012)
L-3,3′,5-triiodothyronine (T3) administration upregulates nuclear factor-E2-related factor 2 (Nrf2) in rat liver, which is redox-sensitive transcription factor mediating cytoprotection. In this work, we studied the role ...
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
(2018)
The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. These pathways include activation of Ca2+ ...
A via Nrf2 participa da maior modulação endotelial induzida pela prenhez sobre reatividade de aortas à fenilefrina.
(Universidade Estadual Paulista (Unesp), 2020-09-08)
Alterações em diferentes vias de sinalização levam a disfunção vascular e endotelial e consequentemente a hipertensão. A hipertensão está relacionada diretamente com o aumento da produção de espécies reativas de oxigênio ...
Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566
(Wiley, 2017)
Fragile X-associated disorders are a family of genetic conditions resulting from the partial or complete loss of fragile X mental retardation protein (FMRP). Among these disorders, fragile X syndrome (FXS) is the most ...
Efecto del estrés crónico emocional sobre la regulación de la expresión y actividad de NRF2 en el hipocampo ventral de ratas macho y hembra
(Universidad de Chile, 2022)
Los estudios epidemiológicos han demostrado que las mujeres tienen una mayor incidencia de trastornos del estado de ánimo, como ansiedad y depresión mayor, que los hombres. Ambos trastornos están asociados con el estrés, ...
Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis
(2017-05-01)
Protandim and 6-gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenous antioxidant enzymes. In this study, we evaluated the effects of these products on the ...
Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2
(PERGAMON-ELSEVIER SCIENCE LTD, 2006)
The properties of bucillamine, a synthetic antioxidant, have been attributed mainly to the donation of thiol groups to glutathione (GSH). We recently demonstrated that glutamatecysteine ligase catalytic subunit (GCLC), the ...