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Parabens inhibit hNaV 1.2 channels
(Elsevier Masson, 2020-08)
Propylparaben, a commonly used antimicrobial preservative, has been reported as an anticonvulsant agent targeting neuronal Na+ channels (NaV). However, the specific features of the NaV channel inhibition by this agent have ...
A cAMP regulated K+-selective channel from the sea urchin sperm plasma membrane
(Academic Press Inc., 1996)
Ion channels are deeply involved in sperm physiology. In sea urchin sperm cyclic nucleotide levels increase during quimotaxis and in the acrosome reaction (AR). Although cyclic nucleotides are second messengers known to ...
Geração e caracterização molecular de anticorpos contra canais para sódio voltagem dependentes
(Universidade Federal de Minas GeraisUFMG, 2012-11-05)
Voltage-gated sodium channels (Nav) are ion channels responsible for the initiation and propagation of action potentials in electrically excitable cells. These channels are expressed in metastatic cells of several types ...
A new class of neurotoxin from wasp venom slows inactivation of sodium current
(Blackwell Science, 2000-06-01)
The effects of alpha-pompilidotoxin (alpha-PMTX), a new neurotoxin isolated from the venom of a solitary wasp, were studied on the neuromuscular synapses in lobster walking leg and the rat trigeminal ganglion (TG) neurons. ...
Non-selective cation channels and oxidative stress- induced cell swelling
(Sociedad de Biología de Chile, 2002)
Ion conduction in substates of the batrachotoxin-modified Na+ channel from toad skeletal muscle
(1993)
Batrachotoxin-modified Na+ channels from toad muscle were inserted into planar lipid bilayers composed of neutral phospholipids. Single-channel conductances were measured for [Na+] ranging between 0.4 mM and 3 M. When ...
Na+ channel regulation by Ca2+/calmodulin and Ca 2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes
(Oxford University Press, 2010-02)
Aims Calmodulin (CaM) regulates Na+ channel gating through binding to an IQ-like motif in the C-terminus. Ca2+/CaM-dependent protein kinase II (CaMKII) regulates Ca2+ handling, and chronic overactivity of CaMKII is associated ...