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Alpha 7 nicotinic acetylcholine receptor modulates lymphocyte activation
(Pergamon-Elsevier Science Ltd, 2009-09-09)
Aims: Even though the presence of α7 nicotinic receptor (nAChR) in lymphocytes has been demonstrated, its functional role still remains elusive. The aim of our study was to characterize α7 nAChRs in human lymphocytes upon ...
Preservation of Alpha-3 Neuronal Nicotinic Acetylcholine Receptor Expression in Sympathetic Ganglia After Brain Death
(HUMANA PRESS INCTOTOWA, 2012-04)
The goal of this study was to evaluate if the immunohistochemical expression of alpha-3 neuronal nicotinic acetylcholine receptor subunit in sympathetic ganglia remains stable after brain death, determining the possible ...
Sensitization-dependent nicotine place preference in the adult zebrafish
(Pergamon-Elsevier Science Ltd, 2019-06)
Sensitization of motor activity is a behavioural test to evaluate the effects of psychostimulants. Conditioned place preference (CPP) is an associative learning procedure to examine the rewarding properties of drugs. We ...
Dysregulation of Neuronal Nicotinic Acetylcholine Receptor-Cholesterol Crosstalk in Autism Spectrum Disorder
(Frontiers Media, 2021-10)
Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, ...
Nongenomic effects of steroids on the nicotinic acetylcholine receptor
(Elsevier, 2000-12)
Nongenomic effects of steroids on the nicotinic acetylcholine receptor. A fast signaling mode of natural and synthetic steroids is exerted on some ion channels and cell-surface receptors. This activity contrasts with their ...
Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis
(Shenyang Editorial Dept Neural Regeneration Res, 2021-02)
Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most ...
In silico characterization of cytisinoids docked into an acetylcholine binding protein
(PERGAMON-ELSEVIER SCIENCE LTD, 2010-05-06)
Homology models of nicotinic acetylcholine receptors (nAChRs) suggest that subtype specificity is due to
non-conserved residues in the complementary subunit of the ligand-binding pocket. Cytisine and its
derivatives ...
Activity of cytisine and its brominated isosteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors
(2001)
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine (5-Br-cy) and 3,5-dibromocytisine (3,5-diBr-cy) on human (h) α7-, α4β2- and α4β4 nicotinic acetylcholine (nACh) receptors, expressed in Xenopus oocytes ...
Neonicotinic analogues: Selective antagonists for a4b2 nicotinic acetylcholine receptors
(Elsevier, 2013)
Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs)that has been extensively used as a
template for the synthesis of a4b2-prefer ring nAChRs.Here,we used the N-methyl-pyrrolidine moiety
of nicotine to ...