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Synthesis, antioxidant and anti-inflammatory properties of an apocynin-derived dihydrocoumarin
(2017-01-01)
Background: Coumarin derivatives as dihydrocoumarins have been reported to have multiple biological activities, such as antioxidant and anti-inflammatory properties. Apocynin (APO), which is a substituted-methoxy-catechol, ...
Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: Effects of nitrosothiol exposure
(ELSEVIER SCIENCE INC, 2009)
Mechanisms regulating NADPH oxidase remain open and include the redox chaperone protein disulfide isomerase (PDI). Here, we further investigated PDI effects on vascular NADPH oxidase. VSMC transfected with wild-type PDI ...
The reactivity of oytho-methoxy-substituted catechol radicals with sulfhydryl groups: Contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin
(Elsevier B.V., 2007-08-01)
Redox processes are involved in the mechanism of action of NADPH oxidase inhibitors such as diphenyleneiodonium and apocynin. Here, we studied the structure-activity relationship for apocynin and analogous ortho-methoxy- ...
Efecto de clobenzorex y melatonina sobre la expresión génica y actividad enzimática de NADPH oxidasa y óxido nítrico sintasa en personas obesas
(2011-11-24)
Obesity is a chronic disease that is established by an imbalance between intake and energy expenditure, increases the risk of producing disorders such as insulin resistance and elevated cholesterol, which lead to the ...
Diseño y Evaluación Teórica y Experimental in vitro de Compuestos Derivados de Apocinina como Posibles Inhibidores de NADPH oxidasa
(2011-06-28)
The oxidative stress produced by high concentrations of superoxide anion O2•- derived from NADPH oxidase 2 (Nox2) in the vascular endothelium has been linked to cardiovascular diseases such as hypertension and atherosclerosis ...
The reactivity of oytho-methoxy-substituted catechol radicals with sulfhydryl groups: Contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin
(Elsevier B.V., 2007-08-01)
Redox processes are involved in the mechanism of action of NADPH oxidase inhibitors such as diphenyleneiodonium and apocynin. Here, we studied the structure-activity relationship for apocynin and analogous ortho-methoxy- ...
Estudo da relação entre estrutura química e atividade biológica de inibidores de NADPH Oxidase em leucócitos: relevância da oxidabilidade e hidrofobicidadeStudy of Relationship Between Chemical Structure and Biological Activity of NADPH Oxidase Inhibitors in Leukocyte: relevance of Oxidisability and hydrophobicity
(Universidade Estadual Paulista (Unesp), 2016)
Papel do receptor B2 das cininas e da NADPH-oxidase no dano secundário associado ao traumatismo cranioencefálico em camundongos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2013-11-22)
Traumatic brain injury (TBI) is a major cause of death and disability. This condition results in neurological and cognitive impairment. In this context, it has been demonstrated that bradykinin, the main metabolite of the ...
Inibição sistêmica da NADPH oxidase: estudo do coração de ratos espontaneamente hipertensos com diabetes mellitus
(Universidade Estadual Paulista (Unesp), 2015-02-26)
Cardiovascular diseases (CVD) are the major cause of morbidity and mortality worldwide. Diabetes mellitus (DM) and arterial hypertension (AH) are the main risk factors for the development of CVD. The coexistence of diabetes ...
NADPH oxidase activity: Spectrophotometric determination of superoxide using pyrogallol red
(Academic Press Inc., 2017)
© 2017 Elsevier Inc.A simple and fast spectrophotometric methodology able to quantify superoxide released by NADPH oxidase from differentiated promyelocytic leukaemia (HL-60) cells using pyrogallol red is described.The ...