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The MED30 subunit of mediator complex is essential for early plant development and promotes flowering in arabidopsis thaliana
(Company of Biologists, 2019-05)
Mediator is a large multiprotein complex that is required for the transcription of most, if not all, genes transcribed by RNA Polymerase II. A core set of subunits is essential to assemble a functional Mediator in vitro ...
Estrogen receptor-α promotes endothelial cell motility through focal adhesion kinase
(Oxford University Press, 2011-04)
Sex steroids play a key role in cell movement and tissue organization. Cell migration requires the integration of events that induce changes in cell structure such as protrusion, polarization and traction toward the direction ...
Contribution of autophagy to antiviral immunity
(2015)
Although identified in the 1960's, interest in autophagy has significantly increased in the past decade with notable research efforts oriented at understanding as to how this multi-protein complex operates and is regulated. ...
The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology
(ELSEVIER, 2008-01)
Apoptosis is essential for maintenance of tissue homeostasis and its deregulation underlies many disease conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death, comprising ...
ER stress signaling and the BCL-2 family of proteins: From adaptation to irreversible cellular damage
(2007)
Programmed cell death is essential for the development and maintenance of cellular homeostasis, and its deregulation results in a variety of pathologic conditions. The BCL-2 family of proteins is a group of evolutionarily ...
Rapid estrogen and progesterone signaling to dendritic spine formation via cortactin/wave1-ARP2/3 complex
(Karger, 2019-12-09)
Synaptic plasticity is the neuronal capacity to modify the function and structure of dendritic spines (DS) in response to neuromodulators. Sex steroids, particularly 17β-estradiol (E2) and progesterone (P4), are key ...
An apomixis-linked ORC3-like pseudogene is associated with silencing of its functional homolog in apomictic Paspalum simplex
(Oxford University Press, 2016-03)
Apomixis in plants consists of asexual reproduction by seeds. Here we characterized at structural and functional levels an apomixis-linked sequence of Paspalum simplex homologous to subunit 3 of the ORIGIN RECOGNITION ...
A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization
Bone integrity depends on a finely tuned balance between bone synthesis by osteoblasts and resorption by osteoclasts. The secretion capacity of mature osteoblasts requires strict control of proteostasis. Endoplasmic ...
Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold
(2019)
Thy-1/CD90 is a glycoprotein attached to the outer face of the plasma membrane with various functions, which depend on the context of specific physiological or pathological conditions. Many of these reported functions for ...
The UPRosome-decoding novel biological outputs of IRE1 alpha function
(Company Biologists, 2020)
Different perturbations alter the function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins in its lumen, a condition termed ER stress. To restore ER proteostasis, a highly conserved ...