Buscar
Mostrando ítems 31-40 de 719
Medicinal chemistry targeting mitochondria: From new vehicles and pharmacophore groups to old drugs with mitochondrial activity
(MDPI, 2020)
Interest in tumor cell mitochondria as a pharmacological target has been rekindled in recent years. This attention is due in part to new publications documenting heterogenous characteristics of solid tumors, including ...
Drug-induced mitochondrial dysfunction and neurotoxicity
(Nova Science Publishers, 2019)
Mitochondria exerts numerous physiological functions such as energy production and maintainance of calcium homeostasis. The brain is a tissue highly dependent on energy production; 20% of total oxygen consumption is used ...
NO control of mitochondrial function in normal and transformed cells
(Elsevier Science Bv, 2017)
Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control ...
Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes
(Elsevier Science BvAmsterdamHolanda, 2012)
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia
(Elsevier Academic Press Inc, 2004-12)
This chapter focuses on role of ubiquinol (UQ) and nitric oxide in endotoxemia. UQ is endogenously synthesized in every organ in a specific pathway branched from cholesterol biosynthesis. Organs have different ubiquinol ...
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress
(2019)
Close contacts between endoplasmic reticulum and mitochondria enable reciprocal Ca2+ exchange, a key mechanism in the regulation of mitochondrial bioenergetics. During the early phase of endoplasmic reticulum stress, this ...
Mitochondrial dynamics, mitophagy and cardiovascular disease
(WILEY-BLACKWELL, 2016)
Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or myocardial injury, and allows the heart to meet an increased demand for oxygen. Although initially beneficial, hypertrophy can ...