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Semi-empirical quantum evaluation of peptide – MHC class II binding
(2017)
Peptide presentation by the major histocompatibility complex (MHC) is a key process for triggering a specific immune response. Studying peptide-MHC (pMHC) binding from a structural-based approach has potential for reducing ...
The half life of TCR/pMHC interaction can modulate T cell activation in response to
(2007)
T cell activation results from T cell receptor (TCR) engagement by cognate peptide-MHC (pMHC) complexes on the surface of antigen presenting cells (APCs). We have previously shown that the half-life of the TCR/pMHC interaction ...
Citrullination only infrequently impacts peptide binding to HLA class II MHC
(Public Library of Science, 2017-05)
It has been hypothesized that HLA class II alleles associated with rheumatoid arthritis (RA) preferentially present self-antigens altered by post-translational modification, such as citrullination. To understand the role ...
Quantum chemical analysis of MHC-peptide interactions for vaccine design
The development of an adequate immune response against pathogens is mediated by molecular interactions between different cell types. Among them, binding of antigenic peptides to the Major Histocompatibility Complex (MHC) ...
Dataset size and composition impact the reliability of performance benchmarks for peptide-MHC binding predictions
(BioMed Central, 2014-07)
BACKGROUND: It is important to accurately determine the performance of peptide:MHC binding predictions, as this enables users to compare and choose between different prediction methods and provides estimates of the expected ...
NetH2pan: A computational tool to guide MHC peptide prediction on murine tumors
(American Association for Cancer Research, 2018-06)
With the advancement of personalized cancer immunotherapies, new tools are needed to identify tumor antigens and evaluate T-cell responses in model systems, specifically those that exhibit clinically relevant tumor ...
Semi-empirical quantum evaluation of peptide – MHC class II binding
Peptide presentation by the major histocompatibility complex (MHC) is a key process for triggering a specific immune response. Studying peptide-MHC (pMHC) binding from a structural-based approach has potential for reducing ...
Electrostatic potential as a tool to understand interactions between malaria vaccine candidate peptides and MHC II molecules
One of the most important problems in vaccine development consists in understanding receptor-ligand interactions between Class II Major Histocompatibility Complex molecules (MHC II) and antigenic peptides involved in ...