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Can ceftazidime-avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?
(American Society for Microbiology, 2017-04)
Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ-AVI) with aztreonam (ATM) against carbapenem-resistant ...
Crystal structure and kinetic analysis of the class B3 di-zinc metallo-β-lactamase LRA-12 from an Alaskan soil metagenome
(Public Library of Science, 2017-07)
We analyzed the kinetic properties of the metagenomic class B3 β-lactamase LRA-12, and determined its crystallographic structure in order to compare it with prevalent metallo-β-lac-tamases (MBLs) associated with clinical ...
The urgent need for metallo-β-lactamase inhibitors: an unattended global threat
(Elsevier Ltd, 2022)
Caracterização molecular de Pseudomonas aeruginosa resistentes a carbapenêmicos e produtoras de metalo-β-lactamase isoladas em hemoculturas de crianças e adolescentes com câncer
(Sociedade Brasileira de Medicina Tropical - SBMT, 2010-08-01)
INTRODUCTION: The objective of this study was to evaluate the prevalence and dissemination of carbapenem-resistant and metallo-β-lactamase-producing Pseudomonas aeruginosa isolated from blood-stream samples (2000-2005) ...
Crystal structure of the metallo-β-lactamase GOB in the periplasmic dizinc form reveals an unusual metal site
(American Society for Microbiology, 2016-10)
Metallo-beta-lactamases (MBLs) are broad-spectrum, Zn(II)-dependent lactamases able to confer resistance to virtually every β-lactam antibiotic currently available. The large diversity of active-site structures and metal ...