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MAPK and angiotensin II receptor in kidney of newborn rats from losartan-treated dams
(SPRINGER, 2008)
Several lines of evidence suggest that angiotensin II (A-II) participates in the postnatal development of the kidney in rats. Many effects of A-II are mediated by mitogen-activated protein kinase (MAPK) pathways. This study ...
Análise da expressão das proteínas KRAS, BRAF e MEK da via de sinalização intracelular mitogen activated protein kinases (MAPK) no carcinoma hepatocelular associado a hepatopatia crônica de diferentes etiologias
(Universidade Federal de Minas GeraisBrasilMEDICINA - FACULDADE DE MEDICINAPrograma de Pós-Graduação em Ciências Aplicadas à Saúde do AdultoUFMG, 2018-08-10)
Introduction: hepatocellular carcinoma (HCC), a very aggressive cancer, common in adults, can be initiated by factors like infection with hepatitis B virus (HBV) and regeneration of the liver induced by chronic diseases. ...
Involvement of PI3K/Akt and p38 MAPK in the induction of COX-2 expression by bacterial lipopolysaccharide in murine adrenocortical cells
(Elsevier Ireland, 2014-03)
Previous studies from our laboratory demonstrated the involvement of COX-2 in the stimulation of steroid production by LPS in murine adrenocortical Y1 cells, as well as in the adrenal cortex of male Wistar rats. In this ...
Effect of Mussel`s Gender and Size on a Stress Response Biomarker
(SPRINGER, 2011)
In mussels, stress signals such as heat, osmotic shock and hypoxia lead to the activation of the phosphorylated p38 mitogen activated protein kinase (pp38-MAPK). This stress activated protein has been efficiently used as ...
The role of mitogen- and stress-activated protein kinase pathways in melanoma
(Wiley, 2011-10-10)
Recent discoveries have increased our comprehension of the molecular signaling events critical for melanoma development and progression. Many oncogenes driving melanoma have been identified, and most of them exert their ...
Dissection of MAPK signaling specificity through protein engineering in a developmental context
(BioMed Central, 2018-04)
Background: Mitogen-activated protein kinases (MAPK) signaling affects many processes, some of which have different outcomes in the same cell. In Arabidopsis, activation of a MAPK cascade consisting of YODA, MKK4/5 and ...
Oxidative stress induces senescence and sterile inflammation in murine amniotic cavity
(2018-03-01)
Objective: A physiologic increase of reactive oxygen species (ROS) is observed through pregnancy. ROS-induced damage to major cellular elements, specifically protein peroxidation, can lead to fetal and placental tissue ...
Adaptação metabólica em granulócitos humanos induzida pelo processo de envelhecimento e Diabetes Mellitus: papel das vias de sinalização cAMP/PKA, Akt/PKB, p38 MAPK e fosfoinositídeos.
(Universidade Federal de Minas GeraisUFMG, 2006-03-22)
A putative mechanism of age-related synaptic dysfunction based on the impact of IGF-1 receptor signaling on synaptic CaMKIIα phosphorylation
(Frontiers Research Foundation, 2018-05)
Insulin-like growth factor 1 receptor (IGF-1R) signaling regulates the activity and phosphorylation of downstream kinases linked to inflammation, neurodevelopment, aging and synaptic function. In addition to the control ...
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
(Lippincott, Williams & Wilkins, 2017)