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CD20, generalidades básicas-moleculares y su posible relación como marcador de mal pronóstico en leucemia
(2023)
CD20 is a transmembrane protein expressed on the surface of the B lymphocyte and plays a significant role in its development and differentiation. It is expressed in most B-cell neoplasms, such as Acute Lymphoblastic Leukemia ...
Methylation status regulates LPL expression in Chronic Lymphocytic Leukemia
(Taylor & Francis Ltd, 2013-08)
Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite ...
Spontaneous apoptosis in chronic lymphocytic leukemia and its relationship to clinical and cell kinetic parameters
(Wiley-lissNew YorkEUA, 2001)
Lymphocyte proliferation and apoptosis of lymphocyte subpopulations in bovine leukemia virus-infected dairy cows with high and low proviral load
(Elsevier Science, 2018-12)
Bovine leukemia virus (BLV) is one of the most important virus in dairy cattle. The infection behavior follows what we call the iceberg phenomenon: 60% of infected animals do not show clinical signs; 30% develop persistent ...
SEPT10 expression in chronic lymphocytic leukemia. Correlation with clinical and biological prognostic factors
(Scientific Research, 2013-10)
Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. Microarray studies allowed highlight genes differentially expressed in this pathology. In this study, we have evaluated the prognostic ...
Revisiting the role of interleukin-8 in chronic lymphocytic leukemia
(Nature Publishing Group, 2017-12)
The proliferation and survival of malignant B cells in chronic lymphocytic leukemia (CLL) depend on signals from the microenvironment in lymphoid tissues. Among a plethora of soluble factors, IL-8 has been considered one ...
Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia
(Ferrata Storti Foundation, 2020-01)
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal Bcellsin peripheral blood and lymphoid tissues 1. Circulating CLL cells are non-dividing Blymphocytes, but a significant fraction of the ...
Immunoregulatory effects of Lurbinectedin in chronic lymphocytic leukemia
(Springer, 2020-02-13)
Despite significant therapeutic improvements chronic lymphocytic leukemia (CLL) remains an incurable disease and there is a persistent pursuit of new treatment alternatives. Lurbinectedin, a selective inhibitor of active ...
Acute lymphocytic leukemiaLeucemia linfocítica aguda
(HCPA/FAMED/UFRGS, 2022)
Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Indole-3-acetic acid (IAA), when oxidized by horseradish peroxidase (HRP), is transformed into cytotoxic molecules capable of inducing cell injury. The aim of this study was to test if, by targeting hematopoietic tumors ...