Buscar
Mostrando ítems 31-40 de 122
Docking Simulation of the Binding Interactions of Saxitoxin Analogs Produced by the Marine Dinoflagellate Gymnodinium catenatum to the Voltage-Gated Sodium Channel Nav1.4
(Multidisciplinary Digital Publishing Institute, 2016)
Tracking the Molecular Evolution of Calcium Permeability in a Nicotinic Acetylcholine Receptor
(Oxford University Press, 2014-09)
Nicotinic acetylcholine receptors are a family of ligand-gated nonselective cationic channels that participate in fundamental physiological processes at both the central and the peripheral nervous system. The extent of ...
Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content
(Pergamon-Elsevier Science Ltd, 2016-07)
tThe activity of positive allosteric modulators (PAMs) of 7 nicotinic acetylcholine receptors (AChRs),including 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), 3-furan-2-yl-N-o-tolylacrylamide (PAM-3), and3-furan-2-yl-N-pheny ...
Activation and modulation of the nicotinic receptor
(IOS Press, 2010-05-27)
Nicotinic acetylcholine receptors (AChRs) are the best characterized ion channels representing the Cys-loop receptor superfamily. AChRs have all the machinery to recognize the neurotransmitter ACh and other agonists such ...
Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities
(2020-12-01)
Snake venom serine proteases (SVSPs) are complex and multifunctional enzymes, acting primarily on hemostasis. In this work, we report the hitherto unknown inhibitory effect of a SVSP, named collinein-1, isolated from the ...
Single-Channel Kinetic Analysis for Activation and Desensitization of Homomeric 5-HT3A Receptors
(Cell Press, 2009-09)
The 5-HT3A receptor is a member of the Cys-loop family of ligand-gated ion channels. To perform kinetic analysis, we mutated the 5-HT3A subunit to obtain a high-conductance form so that single-channel currents can be ...
Interaction of Barbiturate Analogs with the Torpedo californica Nicotinic Acetylcholine Receptor Ion Channel
(American Society for Pharmacology and Experimental Therapeutics, 2001-09)
Barbiturate-induced anesthesia is a complex mechanism that probably involves several ligand-gated ion channel superfamilies. One of these superfamilies includes the archetypical nicotinic acetylcholine receptor (nAChR), ...
Correction to "Conformational Dynamics of the Nicotinic Acetylcholine Receptor Channel: A 35-ns Molecular Dynamics Simulation Study"
(American Chemical Society, 2015-03)
The nicotinic acetylcholine receptor (AChR) is the paradigm of ligand-gated ion channels, integral membrane proteins that mediate fast intercellular communication in response to neurotransmitters. A 35-ns molecular dynamics ...
MUTAGENESIS AND TEMPERATURE-SENSITIVE LITTLE MACHINES
(INTECH, 2012)
In mammals a class of ion channels able to sense a wide range of temperatures (0-60 °C) has evolved. These molecular thermodynamic machines called thermo Transient Receptor Potential (thermoTRP) are spread through the ...