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Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors
(Wiley-liss, Div John Wiley & Sons Inc, 2009-11)
The dopamine D4 receptor (D4R) is predominantly expressed in the prefrontal cortex, a brain area that integrates motor, rewarding, and cognitive information. Because participation of D4Rs in executive learning is largely ...
Failure of Intravenous Morphine to Serve as an Effective Instrumental Reinforcer in Dopamine D2 Receptor Knock-Out Mice
(Society for Neuroscience, 2002-05)
The rewarding effects of opiates are thought to be mediated through dopaminergic mechanisms in the ventral tegmental area, dopamine-independent mechanisms in the nucleus accumbens, or both. The purpose of the present study ...
Remyelination in experimentally demyelinated connexin 32 Knockout mice
(São Paulo, 2009)
Este estudo visou avaliar o papel da conexina 32 (Cx 32) durante a remielinização no sistema nervoso periférico. Uma injeção local de 0,1% de solução de brometo de etídio foi realizada no nervo ciático de camundongos ...
Remyelination in experimentally demyelinated connexin 32 KnockOut mice
(Academia Brasileira de Neurologia - ABNEURO, 2009)
The aim of this study was to evaluate the role of connexin 32 (Cx 32) during remyelination of the peripheral nervous system, through a local injection of either 0,1% ethidium bromide solution or saline in the sciatic nerve ...
The use of kinin B-1 and B-2 receptor knockout mice and selective antagonists to characterize the nociceptive responses caused by kinins at the spinal level
(Elsevier B.V., 2002-12-01)
The mechanisms by which kinins induce hyperalgesia in the spinal cord were investigated by using B-1 or B-2 knockout mice in conjunction with kinin selective agonists and antagonists. the i.t. administration of the kinin ...
Hypothermia during endotoxemic shock in female mice lacking inducible nitric oxide synthase
(LIPPINCOTT WILLIAMS & WILKINS, 2008)
The present study was undertaken to evaluate: (1) whether lipopolysaccharide LPS-incluced hypothermic responses may be altered during two estrous cycle phases, proestrus and diestrus, and after ovariectomy, followed by ...
Alveolar socket healing in 5-lipoxygenase knockout aged female mice treated or not with high dose of zoledronic acid
(2021-12-01)
This study investigated the role 5-lypoxigenase (5-LO) on alveolar socket healing in aged female mice treated with zoledronic acid (ZL). Forty 129/Sv female mice (64–68 weeks old), 20 wild type (WT) and 20 5-LO knockout ...