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Novel anti-thrombotic mechanisms mediated by mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems
The risk of thrombosis, a globally growing challenge and a major cause of death, is influenced by
various factors in the intravascular coagulation, vessel wall, and cellular systems. Among the
contributors to thrombosis, ...
The use of kinin B-1 and B-2 receptor knockout mice and selective antagonists to characterize the nociceptive responses caused by kinins at the spinal level
(Elsevier B.V., 2002-12-01)
The mechanisms by which kinins induce hyperalgesia in the spinal cord were investigated by using B-1 or B-2 knockout mice in conjunction with kinin selective agonists and antagonists. the i.t. administration of the kinin ...
Kinin B1 receptor deficiency attenuates cisplatin-induced acute kidney injury by modulating immune cell migration
(Springer, 2014-04-01)
Cisplatin is a chemotherapeutic agent that causes severe renal dysfunction. the kinin B1 receptor has been associated with the migration of immune cells to injured tissue as well as with renal inflammation. To examine the ...
Neuronal differentiation of P19 embryonal carcinoma cells depends on autocrine stimulation of B2-kinin receptors
(Elsevier B.V., 2006-12-01)
The role of kinin B-1 and B-2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice
(Wiley-Blackwell, 2010-02-01)
Background and purpose:Activation of the proteinase-activated receptor-2 (PAR-2) induces scratching behaviour in mice. Here, we have investigated the role of kinin B-1 and B-2 receptors in the pruritogenic response elicited ...
Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta
(Associação Brasileira de Divulgação Científica, 2007-05-01)
Previous studies have shown that the vascular reactivity of the mouse aorta differs substantially from that of the rat aorta in response to several agonists such as angiotensin II, endothelin-1 and isoproterenol. However, ...
Kinin B1 receptors mediate depression-like behavior response in stressed mice treated with systemic E. coli lipopolysaccharide
(BioMed Central, 2010)
BACKGROUND: Kinin B1 receptors are inducible molecules up-regulated after inflammatory stimuli. This study evaluated the relevance of kinin B1 receptors in a mouse depression behavior model. METHODS: Mice were exposed to ...
Role of kinin B1 and B2 receptors in the development of pilocarpine model of epilepsy
(Elsevier B.V., 2004-07-02)
The tissue sclerosis found in epilepsy of limbic origin is characterized by shrunken gliotic hippocampus, granule cell loss in the dentate gyrus and extensive pyramidal cell loss in Ammon's horn. Evidence has indicated ...
Kinin B1 receptors mediate depression-like behavior response in stressed mice treated with systemic E. coli lipopolysaccharide
(BioMed Central, 2010)
BACKGROUND: Kinin B1 receptors are inducible molecules up-regulated after inflammatory stimuli. This study evaluated the relevance of kinin B1 receptors in a mouse depression behavior model. METHODS: Mice were exposed to ...