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Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats
(Hindawi Ltd, 2018-01-01)
Parecoxib, a selective COX-2 inhibitor, is used to improve analgesia in postoperative procedures. Here we evaluated whether pretreatment with a single dose of parecoxib affects the function, cell injury, and inflammatory ...
Hyperbaric Oxygen Therapy Induces Kidney Protection in an Ischemia/Reperfusion Model in Rats
(ELSEVIER SCIENCE INCNEW YORK, 2012)
Ischemia/reperfusion (I/R) injury remains a major cause of graft dysfunction, which impacts short- and long-term follow-up. Hyperbaric oxygen therapy (HBO), through plasma oxygen transport, has been currently used as an ...
Angiotensin ii type 2 receptor agonist, compound 21, prevents tubular epithelial cell damage caused by renal ischemia
(Pergamon-Elsevier Science Ltd, 2021-12)
During ischemic acute kidney injury (AKI), loss of cytoskeletal integrity and disruption of intercellular junctions are rapid events in response to ATP depletion. Angiotensin II type 2 receptor (AT2R) is overexpressed in ...
Interferência do parecoxibe sobre a função renal e lesão de rins submetidos ao estresse isquêmico: trabalho experimental em ratos com uso de NGAL como marcador da função renalParacoxib interference on the function and tissue injury of kidney subject to ischemic stress: experimental study performed in rats using NGAL as a blomarker of kidney function
(Universidade Estadual Paulista (Unesp), 2015)
Effects of sirolimus alone or in combination with cyclosporine A on renal ischemia/reperfusion injury
(Associação Brasileira de Divulgação Científica, 2010)
Calcineurin inhibitors exacerbate ischemic injury in transplanted kidneys, but it is not known if sirolimus protects or exacerbates the transplanted kidney from ischemic injury. We determined the effects of sirolimus alone ...
Transcriptome Analysis of Renal Ischemia/Reperfusion Injury and Its Modulation by Ischemic Pre-Conditioning or Hemin Treatment
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2013-08-02)
Ischemia/reperfusion injury (IRI) is a leading cause of acute renal failure. The definition of the molecular mechanisms involved in renal IRI and counter protection promoted by ischemic pre-conditioning (IPC) or Hemin ...
Histopathology and laser autofluorescence of ischemic kidneys of rats
(SPRINGER LONDON LTD, 2009)
The purpose of this research was to evaluate the severity of renal ischemia/reperfusion injury as determined by histology and by laser-induced fluorescence (LIF) with excitation wavelengths of 442 nm and 532 nm. Wistar ...
Trimetazidine Protects from Mercury-Induced Kidney Injury
(Karger, 2021-04-13)
Introduction: The presence of mercury in the environment is a worldwide concern. Inorganic mercury is present in industrial materials, is employed in medical devices, is widely used in batteries, is a component of fluorescent ...
A Nitric Oxide-Donor Furoxan Moiety Improves the Efficacy of Edaravone against Early Renal Dysfunction and Injury Evoked by Ischemia/Reperfusion
(Landes Bioscience, 2015-05)
Edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, EDV) is a free-radical scavenger reduces organ ischemic injury. Here we investigated whether the protective effects of EDV in renal ischemia/reperfusion (I/R) ...
CHRONIC NITRIC-OXIDE SYNTHASE INHIBITION AGGRAVATES GLOMERULAR INJURY IN RATS WITH SUBTOTAL NEPHRECTOMY
(Williams & WilkinsBaltimore, 1995)