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Avaliação da toxicidade in vitro e in vivo de moléculas potencialmente terapêuticas
(Universidade Federal de Minas GeraisUFMG, 2018-06-08)
In the development of new medicines, nine out of ten promising candidates entering the clinical phase will not receive approval. Reducing the failure of drug candidates using in vitro assays can reduce the unnecessary use ...
Toxicologia dos cosméticos
(2007-01-01)
Although not desirable, cosmetic products can cause some adverse effects in me user. Such effects can be due bom to individual factors and by inadequate use. So, the safety evaluation must precede the placement of the ...
Toxicologia dos cosméticos
(2007-01-01)
Although not desirable, cosmetic products can cause some adverse effects in me user. Such effects can be due bom to individual factors and by inadequate use. So, the safety evaluation must precede the placement of the ...
In vivo sperm penetration and in vitro sperm migration tests
(Elsevier, 1973)
Two standardized techniques for in vivo and in vitro clinical evaluation of sperm migration are described. The in vivo test consists of postcoital sperm recovery, from the cervical canal and from the uterine cavity, with ...
In vitro and in vivo screening of native lactic acid bacteria toward their selection as a probiotic in broiler chickens
(2015-08)
Among 360 isolates from the gastrointestinal tract (GIT) of broilers, eleven isolates which showed in vitro probiotic properties were identified and selected for further tests. After the in vitro screening, three strains ...
P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies
(Academic Press Inc Elsevier Science, 2020-01)
In vitro studies showed that 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) increases P-glycoprotein (P-gp) expression and activity in Caco-2 cells, preventing xenobiotic toxicity. The present study aimed at ...