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Leukemia (Ph+): diagnosis and treatmentLeucemia Mieloide Crónica (Ph+): diagnóstico y tratamiento
(Universidad de Costa Rica, 2013)
Monitoramento da resposta molecular aos inibidores de tirosino-quinase em pacientes com leucemia mieloide crônica
(Universidade Federal de Santa MariaBrasilCiências da SaúdeUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2019-02-28)
Chronic Myeloid Leukemia (CML) is associated with the chromosome Philadelphia. This abnormal
chromosome forms the chimeric BCR-ABL1 gene, which is responsible for producing a protein with
tyrosine kinase activity. Tyrosine ...
LEUKEMIA (PH +): DIAGNOSIS AND TREATMENTLEUCEMIA MIELOIDE CRÓNICA(PH+): DIAGNÓSTICO Y TRATAMIENTO
(2013-05-30)
Chronic myelogenous leukemia is considered as an exemplary for the development of molecular targeted therapies due to its pathogenesis. This disease is characterized by the presence of Philadelphia chromosome (PH+), a ...
LEUKEMIA (PH +): DIAGNOSIS AND TREATMENTLEUCEMIA MIELOIDE CRÓNICA(PH+): DIAGNÓSTICO Y TRATAMIENTO
(2013-05-30)
Chronic myelogenous leukemia is considered as an exemplary for the development of molecular targeted therapies due to its pathogenesis. This disease is characterized by the presence of Philadelphia chromosome (PH+), a ...
Relationship between SLCO1B(3) and ABCA(3) polymorphisms and imatinib response in chronic myeloid leukemia patients
(Maney Publishing, 2015-04-01)
Background: Genetic variations in membrane transporters may contribute to imatinib mesylate (IM) resistance in chronic myeloid leukemia (CML).Objective: To investigate the relationship between SLCO1B3, SLCO1A2, and ABCA3 ...
MiR-125a-3p and miR-320b differentially expressed in patients with chronic myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation and imatinib mesylate
(2021-10-01)
Chronic myeloid leukemia (CML), a hematopoietic neoplasm arising from the fusion of BCR (breakpoint cluster region) gene on chromosome 22 to the ABL (Abelson leukemia virus) gene on chromosome 9 (BCR-ABL1 oncogene), ...
Dasatinib Overrides Imatinib Resistance Mediated by the F359I Residue Mutation in Two Patients with Chronic Myeloid Leukemia
(KARGERBASEL, 2012)
Despite the beneficial effects of imatinib mesylate, some patients may either not respond or respond suboptimally. Here, we report two chronic myelogenous leukemia patients; one had a suboptimal response according to ...
Perfil de expressão de microRNAs em pacientes com leucemia mieloide crônica tratados com transplante de medula óssea e mesilato de imatinibe
(Universidade Estadual Paulista (Unesp), 2021-02-23)
A leucemia mieloide crônica (LMC) é uma doença mieloproliferativa de células-tronco hematopoiéticas pluripotentes que pode ser dividida em três fases clínicas: crônica, acelerada e crise blástica. É causada por translocação ...
Importance of monitoring and early switch to second generation tyrosine kinase inhibitors for the prognosis of patients with chronic myeloid leukemia with imatinib resistance or intolerance
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, 2011)
Imatinib mesylate was the first BCR-ABL-target agent approved for the treatment of chronic myeloid leukemia. Although most patients respond well to imatinib therapy, the literature shows that one third develops resistance ...
Perfil global de expressão de micro-RNAS circulantes como marcadores de resposta terapêutica na leucemia mielóide crônica
(Universidade Estadual Paulista (Unesp), 2016-03-03)
Chronic Myeloid Leukemia (CML) is a malignant clonal hematopoietic stem cell disease. The discovery of the Philadelphia chromosome and subsequent identification of the gene BCR-ABL have led to understanding the biology of ...