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Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor
(Wiley, 2013-07)
States of growth hormone (GH) resistance, such those observed in Laron dwarf patients, are characterized by mutations in the GH receptor (GHR), decreased serum and tissue IGF-1 levels, impaired glucose tolerance, and ...
IGF-I and INS receptor expression in the salivary glands of diabetic Nod mice submitted to long-term insulin treatment
(Academic Press Ltd Elsevier Science LtdLondonInglaterra, 2008)
Association between IGF-I, IGF-IR and GHRH gene polymorphisms and growth and carcass traits in beef cattle
(Elsevier B.V., 2005-07-01)
Molecular biology techniques are of help in genetic improvement since they permit the identification, mapping and analysis of polymorphisms of genes encoding proteins that act on metabolic pathways involved in economically ...
A Homozygous Mutation in the Highly Conserved Tyr60 of the Mature IGF1 Peptide Broadens the Spectrum of IGF1 Deficiency
(BioScientifica, 2019-09)
Background: IGF1 is a key factor in fetal and postnatal growth. To date, only three homozygous IGF1 gene defectsleading to complete or partial loss of IGF1 activity have been reported in three short patients born small ...
Immunolocalization and effect of low concentrations of Insulin like growth factor-1 (IGF-1) in the canine ovary
(Wiley-Blackwell, 2020-09-07)
Insulin like growth factor-1 (IGF-1) plays an important role in the regulation of ovarian function. Despite its extensive study in several species, there is a paucity of information about IGF-1`s function and localization ...
Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes
(ELSEVIER SCIENCE BV, 1998-01-30)
IGF-1 increased 2-fold protein synthesis in cardiac myocytes. Genistein, whether added during preincubation or with IGF-I at the start of incubation, significantly inhibited the IGF-1-induced stimulation of protein synthesis, ...
Overexpression of the Insulin-like growth factor 1 receptor (IGF-1R) is associated with malignancy in familial pheochromocytomas and paragangliomas
(Wiley, 2013-03)
CONTEXT: Pheochromocytomas and paragangliomas (pheo/pgl) are neuroendocrine tumours derived from chromaffin cells. Although mostly benign, up to 26% of pheo/pgl will undergo malignant transformation. Reliable histological ...
Spatiotemporal distribution of the insulin-like growth factor receptor in the rat olfactory bulb.
(Springer/Plenum Publishers, 2003-01)
Insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) are involved in growth of neurons. In the rat olfactory epithelium, we previously showed IGF-IR immunostaining in subsets of olfactory receptor neurons. We now ...