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Mostrando ítems 31-40 de 132
Caracterização da função do igf2bp-1 no comportamento do osteossarcoma canino
(Universidade Estadual Paulista (Unesp), 2018-12-17)
A medicina comparativa torna-se cada vez mais importante para obtenção de estudos aprofundados em diversas áreas incluindo a oncologia, possibilitando melhor conhecimento da genética do câncer e desenvolvimentos de novas ...
Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor
(Wiley, 2013-07)
States of growth hormone (GH) resistance, such those observed in Laron dwarf patients, are characterized by mutations in the GH receptor (GHR), decreased serum and tissue IGF-1 levels, impaired glucose tolerance, and ...
Three novel IGF1R mutations in microcephalic patients with prenatal and postnatal growth impairment
(Wiley Blackwell Publishing, Inc, 2014-07)
Background: IGF1R gene mutations have been associated with varying degrees of intrauterine and postnatal growth retardation, and microcephaly. Objective To identify and characterize IGF1R gene variations in a cohort of 28 ...
Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging
(Taylor & Francis, 2016-12)
In rats, learning and memory performance decline during normal aging, which is paralleled by a severe reduction of the levels of neurogenesis in the hippocampal dentate gyrus (DG). A promising therapeutic strategy to restore ...
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates
(Springer, 2020)
Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription ...
Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors
(ENDOCRINE SOC, 2008)
Background: Adrenocortical tumors are heterogeneous neoplasms with incompletely understood pathogenesis. IGF-II overexpression has been consistently demonstrated in adult adrenocortical carcinomas. Objectives: The objective ...
Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice
(Nature Publishing Group, 2019-09)
Extracellular vesicles (EVs) can mediate mesenchymal stromal cells (MSCs) paracrine effects. We aimed to evaluate the therapeutic potential of human umbilical cord perivascular cells (HUCPVCs) engineered to produce Insulin ...
Growth hormone pharmacogenetics: the interactive effect of a microsatellite in the IGF1 promoter region with the GHR-exon 3 and-202 A/C IGFBP3 variants on treatment outcomes of children with severe GH deficiency
(NATURE PUBLISHING GROUPLONDON, 2012)
Insulin-like growth factor type 1 (IGF1) is a mediator of growth hormone (GH) action, and therefore, IGF1 is a candidate gene for recombinant human GH (rhGH) pharmacogenetics. Lower serum IGF1 levels were found in adults ...