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Epigenetic mechanisms involved in cisplatin-induced nephrotoxicity: An update
(MDPI, 2021)
Cisplatin is an antineoplastic drug used for the treatment of many solid tumors. Among its
various side effects, nephrotoxicity is the most detrimental. In recent years, epigenetic regulation
has emerged as a modulatory ...
Changes in histone acetylation and methylation that are important for persistent but not transient expression of CCR4 in human CD4(+) T cells
(WILEY-BLACKWELL, 2010)
Although regulation of CXCR3 and CCR4 is related to Th1 and Th2 differentiation, respectively, many CXCR3(+) and CCR4(+) cells do not express IFN-gamma and/or IL-4, suggesting that the chemokine receptor genes might be ...
Histone acetylation and methylation marks in chromatin of Panstrongylus megistus (Hemiptera, Reduviidae)
(2018-08-01)
Panstrongylus megistus, a potential vector of Chagas disease, currently occupies a wider geographic distribution in Brazil than Triatoma infestans, another member of the hemipteran Reduviidae family and a vector of the ...
Use of synthetic peptides for identifying biotinylation sites in human histones
(Humana Press, 2008)
Posttranslational modifications of histones play an important role in the regulation of chromatin structure and, hence, gene regulation. Recently, we have identified a novel modification of histones: binding of the vitamin ...
Multiple levels of epigenetic control for bone biology and pathology
(Elsevier Inc., 2015-04)
Multiple dimensions of epigenetic control contribute to regulation of gene expression that governs bone biology and pathology. Once confined to DNA methylation and a limited number of post-translational modifications of ...
K12-biotinylated histone H4 is enriched in telomeric repeats from human lung IMR-90 fibroblasts
(Elsevier, 2010-04)
Covalent modifications of histones play a role in regulating telomere attrition and cellular senescence. Biotinylation of lysine (K) residues in histones, mediated by holocarboxylase synthetase (HCS), is a novel diet-dependent ...
Changes in tri-methylation profile of lysines 4 and 27 of histone H3 in bovine blastocysts after cryopreservation
(Elsevier B. V., 2015)
Pregnancy rates from cryopreserved embryos remain lower than non-cryopreserved counterparts, even though these embryos appear morphologically normal. How epigenetic events, such as histone modifications, are affected by ...
Expression of non-acetylatable lysines 10 and 14 of histone H4 impairs transcription and replication in Trypanosoma cruzi
(P.T. LoVerde, K.R. Matthews, M. Parsons, A.P. Waters, 2016)