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HDAC inhibition decreases XIST expression on female IVP bovine blastocysts
(2013-01-01)
During initial development, both X chromosomes are active in females, and one of them must be silenced at the appropriate time in order to dosage compensate their gene expression levels to male counterparts. Silencing ...
HDAC inhibition decreases XIST expression on female IVP bovine blastocysts
(2013-01-01)
During initial development, both X chromosomes are active in females, and one of them must be silenced at the appropriate time in order to dosage compensate their gene expression levels to male counterparts. Silencing ...
Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
(Elsevier Ireland, 2018-12)
Radiotherapy is one of the leading treatments for clinical cancer therapy. External beam radiotherapy has been proposed as an adjuvant treatment for patients bearing differentiated thyroid cancer refractory to conventional ...
Trichostatin a promotes the generation and suppressive functions of regulatory T cells
(Hindawi Limited, 2013-05)
Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. They can be generated in the thymus as well as in the periphery through ...
Histone Epigenetic Marks In Heterochromatin And Euchromatin Of The Chagas' Disease Vector, Triatoma Infestans
(Elsevier GMBH, Urban & Fishcer VerlagJena, 2016)
Effects of sodium valproate on the chromatin of Triatoma infestans (Klug, 1834) (Hemiptera, Reduviidae) under in vitro culture conditions
(2021-04-01)
Sodium valproate (VPA) is a classic anticonvulsive, a histone deacetylase inhibitor, and a chromatin remodeling inducer. When injected into specimens of Triatoma infestans, a vector of Chagas disease, VPA affects the ...
HDAC8: a multifaceted target for therapeutic interventions.
(Elsevier Inc, 2016)
Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression
(2016)
Altering chromatin structure through histone posttranslational modifications has emerged as a key driver of transcriptional responses in cells. Modulation of these transcriptional responses by pharmacological inhibition ...
Design and synthesis of hybrid compounds as epigenetic modifiers
(2021-12-01)
Epigenetic modifiers acting through polypharmacology mechanisms are promising compounds with which to treat several infectious diseases. Histone deacetylase (HDAC) enzymes, mainly class I, and extra-terminal bromodomains ...