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UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability
(Oxford University Press, 2013-05)
Although many genotoxic treatments upregulate the cyclin kinase inhibitor p21, agents such as UV irradiation trigger p21 degradation. This suggests that p21 blocks a process relevant for the cellular response to UV. Here, ...
Wwox seletion in mouse B cells leads to genomic instability, neoplastic transformation, and monoclonal gammopathies
(Frontiers Media S.A., 2019-06)
WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature ...
Genomic instability in human actinic keratosis and squamous cell carcinoma
(Faculdade de Medicina / USP, 2011)
OBJECTIVE: To compare the repetitive DNA patterns of human actinic keratoses and squamous cell carcinomas to determine the genetic alterations that are associated with malignant transformation. INTRODUCTION: Cancer cells ...
Acute crack cocaine exposure induces genetic damage in multiple organs of rats
(2016-04-01)
Crack cocaine is a very toxic product derived from cocaine. The aim of this study was to evaluate genetic damage in multiple organs of rats following acute exposure to crack cocaine. A total of 20 Wistar rats were distributed ...
Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients
(2017-04-01)
Astrocytomas are the most common primary brain tumors. They are very resistant to therapies and usually progress rapidly to high-grade lesions. Here, we investigated the potential role of DNA repair genes in astrocytoma ...
Genomic instability related to zinc deficiency and excess in an in vitro model: is the upper estimate of the physiological requirements recommended for children safe?
(Springer, 2017-08)
Micronutrients are important for the prevention of degenerative diseases due to their role in maintaining genomic stability. Therefore, there is international concern about the need to redefine the optimal mineral and ...
Estimating genomic instability mediated by Alu retroelements in breast cancer
(Sociedade Brasileira de Genética, 2014)
Histone Methyltransferase EZH2 Induces Akt-Dependent Genomic Instability and BRCA1 Inhibition in Breast Cancer
(American Association for Cancer Research, 2011-03)
Increased levels of EZH2, a critical regulator of cellular memory, signal the presence of metastasis and poor outcome in breast cancer patients. High levels of EZH2 are associated with nuclear pleomorphism, lack of estrogen ...
Genomic Instability Decreases in HIV Patient by Complementary Therapy with Rosmarinus officinalis Extracts
(Mary Ann Liebert, Inc., 2020-10)
Genomic instability is associated with increased oxidative stress in patients with human immunodeficiency virus (HIV). The aim of this study was to determine the effect of intake of methanolic and aqueous extracts of ...
Possible radio-protective effect of folic acid supplementation on low dose ionizing radiation-induced genomic instability in vitro
(National Institute of Science Communication, 2016-08)
Ionizing radiation induces DNA damage through the production of single-strand breaks, double-strand breaks and reactive oxygen species. Folic acid (FA) can prevent DNA damage. We hypothesized that in vitro supplementation ...