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Mostrando ítems 31-40 de 67
Desarrollo de un panel de pruebas moleculares para detectar mutaciones en los genes NPM1, DNMT3A, IDH1/2 en casos de leucemia mieloide aguda
(Universidad Michoacana de San Nicolás de Hidalgo, 2022-02)
Acute myeloid leukemia (AML) is a neoplasm that arises from stem cells and hematopoietic progenitors. During the course of malignant transformation, these cells undergo continuous genetic and epigenetic evolution and clonal ...
Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells
(Elsevier Science, 2020-01)
Targeting the apoptosis machinery is a promising therapeutic approach in myeloid malignancies. BCL2L1 is a well-known glucocorticoid-responsive gene and a key apoptosis regulator that, when over-expressed, can contribute ...
Alterações moleculares em síndrome mielodisplásica
(Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2006-09-01)
Myelodysplastic syndrome (MDS) is a heterogenous group of clonal hematopoietic disorders. Chromosomal abnormalities detected in this disease were the start to many studies in order to characterize molecular pathogenesis. ...
The Genetic Landscape of the Childhood Cancer Medulloblastoma
(AMER ASSOC ADVANCEMENT SCIENCE, 2011)
Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high-density microarrays and sequenced all ...
Neural modeling of the blood glucose level for type 1 diabetes mellitus patients
(2013)
This paper discusses a novel training algorithm for a neural network architecture applied to time series prediction with smart grids applications. The proposed training algorithm is based on an extended Kalman filter (EKF) ...
Avaliação da frequência das alterações citogenéticas e de expressão gênica em LMA ao diagnóstico e, sequencialmente, na remissão
(Universidade Federal de São Paulo (UNIFESP), 2016-10-18)
Acute myeloid leukemias (AML) are genetic heterogeneous neoplastic diseases. Distinctive clinical features in each subtype requires attention to define the proper disease classification and prognostic factors. With the ...
Molecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazil's Federal District
(Funpec-editoraRibeirao PretoBrasil, 2009)