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G Protein Coupled Receptors: understanding how our body responds to signalsReceptores acoplados a proteínas G: Entendiendo cómo responde nuestro organismo a señales diversas
(Pontificia Universidad Católica del Perú, 2012)
Receptores acoplados à proteína G: implicações para a fisiologia e doenças endócrinas
(Sociedade Brasileira de Endocrinologia e Metabologia, 2001-06-01)
The majority of polypeptide hormones and even extracellular calcium signal their target cells through G protein-coupled receptors (GPCRs). Recently, many mutations have been both identified and associated with several ...
Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase
(Amer Physiological Soc, 2017-07-01)
G protein-coupled receptor kinase isoform 2 (GRK2) has a critical role in physiological and pharmacological responses to endogenous and exogenous substances. Sepsis causes an important cardiovascular dysfunction in which ...
INHIBITION OF GUANYLYL CYCLASE RESTORES NEUTROPHIL MIGRATION AND MAINTAINS BACTERICIDAL ACTIVITY INCREASING SURVIVAL IN SEPSIS
(LIPPINCOTT WILLIAMS & WILKINS, 2011)
Sepsis results from an overwhelming response to infection and is a major contributor to death in intensive care units worldwide. In recent years, we and others have shown that neutrophil functionality is impaired in sepsis. ...
A Latin American Perspective on G Protein-Coupled Receptors
(Amer Soc Pharmacology Experimental Therapeutics, 2016-11-01)
G protein-coupled receptors are sensors that interact with a large variety of elements, including photons, ions, and large proteins. Not surprisingly, these receptors participate in the numerous normal physiologic processes ...
Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism
(Elsevier Science BV, 2018)
The L-type calcium channel (LTCC) is an important determinant of cardiac contractility. Therefore, changes in LTCC activity or protein levels could be expected to affect cardiac function. Several studies describing LTCC ...
The kinin B-1 receptor regulates muscle-specific E3 ligases expression and is involved in skeletal muscle mass control
(Portland Press Ltd, 2014-08-01)
Regulation of muscle mass depends on the balance between synthesis and degradation of proteins, which is under the-control of different signalling pathways regulated by hormonal, neural and nutritional stimuli. Such stimuli ...
Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model.
(American Society for Pharmacology and Experimental Therapeutics, 2003-08-01)
Knowing the importance for research and pharmacological uses of proper ligand classification into agonists, inverse agonists, and antagonists, the aim of this work was to study the behavior of tiotidine, a controversial ...