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CD32 ligation promotes the activation of CD4+T cells
(Frontiers Media SA, 2018-11)
Low affinity receptors for the Fc portion of IgG (FcγRs) represent a critical link between innate and adaptive immunity. Immune complexes (ICs) are the natural ligands for low affinity FcγRs, and high levels of ICs are ...
Effects of cold stress, corticosterone and catecholamines on phagocytosis in mice: differences between resting and activated macrophages
(2010)
Objective: We subjected mice to acute cold stress and studied the effect on phagocytosis by peritoneal macrophages mediated by 3 types of phagocytic receptors: Fcγ, complement receptors 3 (CR3) and mannose and β-glucan ...
Determinação dos genótipos para o polimorfismo dos receptores de IgG, FcγRlla (H/R131) e FcγRIIIb (NA1/NA2), e estudo do burst oxidativo dos neutrófilos em indivíduos infectados pelo HIV e/ou Mycobacterium tuberculosis
(Universidade Estadual Paulista (Unesp), 2011-02-18)
A infecção pelo vírus da imunodeficiência humana (HIV) ocorre com aumento dos níveis de anticorpos séricos e com grande quantidade de imunocomplexos circulantes. A associação entre as disfunções da fagocitose mediadas por ...
Estudio del polimorfismo de receptores Fcγlla en pacientes chilenos con lupus eritematoso sistémicoPolymorphisms of Fcγlla receptors in Chilean patients with systemic lupus erythematosus
(2003-01)
Background: Polymorphisms of Fc receptors for IgG (FcγR) have been proposed as a genetic factor that influences susceptibility for systemic lupus erythematosus (SLE). Human FćRIIa has 2 codominantly expressed alleles, H131 ...
Comparability of Antibody-Mediated Cell Killing Activity Between a Proposed Biosimilar RTXM83 and the Originator Rituximab
(Adis Int Ltd, 2016-06)
BACKGROUND:Biosimilars are described as biological products that resemble the structure of original biologic therapeutic products, with no clinically meaningful differences in terms of safety and effectiveness from the ...
Monocytes and neutrophils from tuberculosis patients are insensitive to anti-inflammatory effects triggered by the prototypic formyl peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP)
(Wiley Blackwell Publishing, Inc, 2003-08)
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis where formyl peptides, which are cleavage products of bacterial and mitochondrial proteins, are present. In this study, we demonstrated that ...
Immune complexes (IC) down-regulate the basal and interferon-γ-induced expression of MHC class II on human monocytes
(Wiley Blackwell Publishing, Inc, 2001-08)
The interaction of Fc receptors for IgG (FcγRs) on monocytes/macrophages with immune complexes (IC) triggers regulatory and effector functions. Previous studies have shown that FcγR-IC interactions inhibit the IFN-γ-induced ...