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Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment
(NATL ACAD SCIENCESWASHINGTON, 2012)
Processes that promote cancer progression such as angiogenesis require a functional interplay between malignant and nonmalignant cells in the tumor microenvironment. The metalloprotease aminopeptidase N (APN; CD13) is often ...
FTY720 and lung tumor development
(Elsevier B.V., 2009-06-01)
FTY720 has been shown to prevent cancer development in experimental models but there is no report whether this beneficial effect is associated with the time point of the drug administration. Lung adenoma was induced in ...
Cigarette smokers? views on their habit and the causes of their illness following lung cancer diagnosis: a clinical-qualitative studyVisão de fumantes sobre seu hábito e sobre as causas de sua doença após o diagnóstico de câncer de pulmão: um estudo clínico qualitativo
(Associação Paulista de Medicina - APM, 2006)
Synergistic interactions of the anti‑casein kinase 2 CIGB‑300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models
(Spandidos Publications, 2014-07)
CIGB‑300 is a novel clinical‑stage synthetic peptide that impairs the casein kinase 2 (CK2)‑mediated phosphorylation of B23/nucleophosmin in different experimental settings and cancer models. As a single agent, CIGB‑300 ...
Delay of lung adenocarcinoma (LAC-1) development in mice by dietary oleic acid
(Lawrence Erlbaum Assoc Inc-taylor & Francis, 2017-10)
Lung cancer is the leading cause of death by cancer, and is a major sanitary concern worldwide. Some nutrients, such as ω-9 fatty acids, have been proposed as anticancer agents. Thus, an olein-enriched diet was assayed in ...
Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization
(Nature, 2020-09-07)
CK2 is a serine/threonine kinase that is overexpressed in breast cancer and its inhibition is associated to reduced tumor growth and disease progression. CIGB-300 is an antitumor peptide with a novel mechanism of action, ...
Independent Radiologic Review in Metastatic Colorectal Cancer: Systematic Review and Meta-Analysis
(Radiological Soc North AmericaOak Brook, 2012)
Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
(MDPI, 2019)
Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration ...