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Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction
(Amer Coll Chest PhysiciansNorthbrookEUA, 2004)
Women with TT genotype for eNOS gene are more responsive in lowering blood pressure in response to exercise
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2010)
Inhibition of epithelial sodium channel (enac) with amilorideimproves endothelium-derived vasodilation in angiotensin ii(aii)-treated rats
(FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, 2011)
ENaC is expressed in the endothelium, and may affect vascular tone, since inhibitors of the mineralocorticoid receptor, ENaC main regulator, produce favorable effects in different types of hypertension, independently of ...
Asymmetric dimethylarginine endogenous inhibition of nitric oxide synthase causes differential vasculature effects
(INT SCIENTIFIC LITERATURE, INC, 2009)
Background: Asymmetric dimethylarginine (ADMA), produced during protein metabolism, is an endogenous inhibitor of nitric oxide synthase, but little is known about its direct vasoactive properties in different arterial beds. ...
Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1−/- mice
(Landes Bioscience, 2019-01)
We have previously provided pharmacological evidence that stimulation of calcium-sensing receptors (CaSR) induces endothelium-dependent relaxations of rabbit mesenteric arteries through activation of heteromeric TRPV4/TRPC1 ...
Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1-/- mice
(Taylor & Francis, 2019)
Abstract: We have previously provided pharmacological evidence that stimulation of calcium-sensing receptors (CaSR) induces endothelium-dependent relaxations of rabbit mesenteric arteries through activation of heteromeric ...
Chronic Ethanol Consumption Induces Cavernosal Smooth Muscle Dysfunction in Rats
(Elsevier Science IncNew YorkEUA, 2009)
Vascular tone regulation induced by C-Type natriuretic peptide: Differences in endothelium-dependent and -independent mechanisms involved in normotensive and spontaneously hypertensive rats
(Public Library of Science, 2016-12)
Given that the role of C-type natriuretic peptide (CNP) in the regulation of vascular tone in hypertensive states is unclear, we hypothesized that impaired response of the nitric oxide system to CNP in spontaneously ...
Chronic Ethanol Consumption Induces Cavernosal Smooth Muscle Dysfunction in Rats
(ELSEVIER SCIENCE INC, 2009)
OBJECTIVES To investigate the effects of chronic ethanol consumption on nitric oxide (NO)-mediated relaxation in rat cavernosal smooth muscle (CSM). METHODS Male wistar rats were divided into 2 groups: control and ethanol. ...