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The estrogen receptor alpha nuclear localization sequence is critical for fulvestrant-induced degradation of the receptor
(Elsevier Ireland, 2015-11)
Fulvestrant, a selective estrogen receptor down-regulator (SERD) is a pure competitive antagonist of estrogen receptor alpha (ERα). Fulvestrant binds ERα and reduces the receptor's half-life by increasing protein turnover, ...
Efeitos da ovariectomia, estrógeno e isoflavonas da soja em glândulas sumandibulares de ratos
(2017-07-01)
Objective: A decrease in granular convoluted tubule (GCT) cells and acini occurs in the submandibular glands of castrated female rats, while in rats submitted to hormone replacement and phytotherapy with soy isoflavones, ...
Perinatal DEHP exposure modulates pituitary estrogen receptor α and β expression altering lactotroph and somatotroph cell growth in prepuberal and adult male rats
(Pergamon-Elsevier Science Ltd, 2021-12)
Phthalates are synthetic chemicals widely used to make polyvinylchloride (PVC) soft and flexible. Of these, Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used, with high human exposure occurring as early as the ...
Multiple mechanisms of regulation of estrogen action in the rat uterus: Effects of insulin
(1983)
Eosinophils appear in the rat uterus in the presence of estrogen. The level of these cells in the uterus depends on the number of blood eosinophils. Insulin is an eosinopenic hormone in the blood and, therefore, could ...
Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells
(Rockefeller University Press, 2018-08)
Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression. Therefore, understanding what activates ERα is critical for cancer ...
Expression and localization of estrogen receptor α in the C2C12 murine skeletal muscle cell line
(Wiley-liss, Div John Wiley & Sons Inc, 2008-07)
The classical model of 17β-estradiol action has been traditionally described to be mediated by the estrogen receptor (ER) localized exclusively in the nucleus. However, there is increasing functional evidence for extra ...
Estrogen receptor β and epidermal growth factor receptor as early-stage prognostic biomarkers of non-small cell lung cancer
(Spandidos Publ Ltd, 2010-07)
As 20% of stage I NSCLC patients develop recurrent and often incurable cancer, the identification of prognostic markers has a meaningful clinical application. The biological significance of steroid hormone and EGF receptors, ...
A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780
(The Physiological Society, 2018-09)
Estradiol plays a critical role in stimulating the fetal hypothalamus?pituitary?adrenal axis at the end of gestation. Estradiol action is mediated through nuclear and membrane receptors that can be modulated by ICI 182,780, ...