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Can drug repurposing strategies be the solution to the COVID-19 crisis?
(Taylor & Francis Ltd, 2020-12)
Introduction: The current COVID-19 pandemic has resulted in disastrous human and economic costs, mainly due to the absence of specific treatments to ameliorate the effects of this emerging viral disease. Complementary to ...
Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models
(Impact Journals LLC, 2017-01)
Discovery of new drugs for cancer treatment is an expensive and time-consuming process and the percentage of drugs reaching the clinic remains quite low. Drug repositioning refers to the identification and development of ...
Reposicionamento dos antidepressivos fluoxetina e paroxetina
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2022-08-23)
The substantial increase in multidrug resistant (MDR) bacteria makes efforts to find more effective antimicrobial therapies urgent. Drug repositioning, defined as the process of investigating new uses for drugs that have ...
Reposicionamento e avaliação da atividade antibacteriana e de clivagem do DNA plasmidial in vitro dos não antibióticos Anlodipino e Valsartana
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2019-12-19)
Infections caused by multiresistant microrganisms have increased considerably in recent years,
reaching approximately one fifth of worldwide mortality, becoming a public health problem. Another
worrying factor is the ...
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing
(Frontiers Research Foundation, 2019-10)
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds ...
Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir
(Elsevier France-editions Scientifiques Medicales Elsevier, 2015-03)
In spite of remarkable advances in the knowledge on Trypanosoma cruzi biology, no medications to treat Chagas disease have been approved in the last 40 years and almost 8 million people remain infected. Since the public ...
In silico Guided Drug Repurposing: Discovery of New Competitive and Non-competitive Inhibitors of Falcipain-2
(Frontiers Media S.A., 2019-08-06)
Malaria is among the leading causes of death worldwide. The emergence of Plasmodium falciparum resistant strains with reduced sensitivity to the first line combination therapy and suboptimal responses to insecticides used ...