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Extracellular Cysteine in Connexins: Role as Redox Sensors
(Lausanne : Frontiers Research Foundation, 2016)
Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening ...
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness
(Springer, 2016)
Gap-junction channels (GJCs) are formed by head-to-head association of two hemichannels (HCs, connexin hexamers). HCs and GJCs are permeable to ions and hydrophilic molecules of up to Mr ~1 kDa. Hearing impairment of genetic ...
Regulation of Connexins Expression Levels by MicroRNAs, an Update
(Frontiers Research Foundation, 2016)
Control of cell-cell coordination and communication is regulated by several factors, including paracrine and autocrine release of biomolecules, and direct exchange of soluble factors between cells through gap junction ...
Functional hemichannels formed by human connexin 26 expressed in bacteria
(© 2015 The Author(s) CC-BY Licence, 2015)
Gap-junction channels (GJCs) communicate the cytoplasm of adjacent cells and are formed by head-to-head association of two hemichannels (HCs), one from each of the neighbouring cells. GJCs mediate electrical and chemical ...
Connexin-Mediated Signaling at the Immunological Synapse
(MDPI, 2020)
The immunological synapse (IS) is an intercellular communication platform, organized at the contact site of two adjacent cells, where at least one is an immune cell. Functional IS formation is fundamental for the modulation ...
Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells
(2020)
Under normal conditions, almost all cell types communicate with their neighboring cells through gap junction channels (GJC), facilitating cellular and tissue homeostasis. A GJC is formed by the interaction of two hemichannels; ...
Trypanosoma cruzi induces changes in cardiac connexin43 expression
(Elsevier, 2018)