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Novel and Uncommon Chromosome Aberrations in Chronic Lymphocytic Leukemia: Cytogenetic, FISH and Clinical Evaluation
(Nova Science Publishers, 2007)
The identification of the non-random genetic alterations associated with cancer has great importance not only to basic research but also to disease management as diagnostic and prognostic markers. In contrast to other types ...
Co-existence of t(6;13)(p21;q14.1) and trisomy 12 in chronic lymphocytic leukemia
(HUMANA PRESS INCTOTOWA, 2012)
We report a case of a 57-year-old man diagnosed with chronic lymphocytic leukemia (CLL) and presence of a rare t(6;13)(p21;q14.1) in association with an extra copy of chromosome 12. Classical cytogenetic analysis using the ...
The use of flow cytometry for diagnosis and immunophenotyping in chronic lymphocytic leukemia in a dog: Clinical case report
(2022)
Background: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in dogs. It is characterized by the proliferation of neoplastic lymphocytes in the bone marrow, which are morphologically normal (mature), ...
Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1
(Nature Publishing Group, 2012-07)
Accumulation of neoplastic cells in chronic lymphocytic leukemia (CLL) is conditioned by a variety of signals delivered by accompanying cells in lymphoid tissues. Here we examined the relevance of galectin-1 (Gal-1), a ...
Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia
(Taylor & Francis, 2013-08)
Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite ...
Chronic lymphocytic leukemia cells bind and present the erythrocyte protein band 3: Possible role as initiators of autoimmune hemolytic anemia
(American Association of Immunologists, 2008-09)
The mechanisms underlying the frequent association between chronic lymphocytic leukemia (CLL) and autoimmune hemolytic anemia are currently unclear. The erythrocyte protein band 3 (B3) is one of the most frequently targeted ...
Chronic lymphocytic leukemia cells increase neutrophils survival and promote their differentiation into CD16 high CD62L dim immunosuppressive subset
(John Wiley & Sons Inc, 2019-09)
Reprogramming of neutrophils by malignant cells is well-described for many types of solid tumors, but data remain scarce for hematological diseases. Chronic lymphocytic leukemia (CLL) is characterized for a deep immune ...
AgNOR clusters as a parameter of cell kinetics in chronic lymphocytic leukaemia
(British Med Journal Publ GroupLondonInglaterra, 1996)
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: Link with an activated microenvironment in CLL disease
(American Society of Hematology, 2010-06)
Interaction of chronic lymphocytic leukemia (CLL) B cells with tissue microenvironment has been suggested to favor disease progression by promoting malignant B-cell growth. Previous work has shown expression in peripheral ...
New advances in chronic lymphocytic leukemia treatment: Biodegradable ZnO hybrid cluster nanoparticle as antineoplastic agents
(Elsevier, 2019)
B-cell chronic disorders like CLL unfortunately remain as uncurable diseases. Our group demonstrated the ability of nanoparticles (NPs) to effectively target and successfully internalize in tumor B cells. We had also focused ...