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Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism
(ELSEVIER SCIENCE BV, 2010)
Autistic children show elevated serum levels of autoantibodies to several proteins essential for the function of normal brains. The voltage-dependent anion channel (VDAC) and hexokinase-I, a VDAC protective ligand, were ...
Potential ligand-binding residues in rat olfactory receptors identified by correlated mutation analysis
(Harwood Acad Publ Gmbh, 1995-01-01)
A family of G-protein-coupled receptors is believed to mediate the recognition of odor molecules. In order to identify potential ligand-binding residues, we have applied correlated mutation analysis to receptor sequences ...
Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors
(2008)
Zinc and copper are indispensable trace metals for life with a recognized role as catalysts in enzyme actions. We now review evidence supporting the role of trace metals as novel allosteric modulators of ionotropic receptors: ...
A structural view of ligand-dependent activation in thermotrp channelsFRONTIERS IN PHYSIOLOGYFRONTIERS RESEARCH FOUNDATION
(FRONTIERS RESEARCH FOUNDATION, 2016)
GABAA receptor family: overview on structural characterization
(Future Science, 2019-02-25)
The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands, which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich pharmacology and therapeutic potential, ...
Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol
(Instituto de Histología y Embriología, 2021-06)
Cholesterol is a major lipid in biological membranes. It not only plays a structural role but also modulates a wide range of functional properties of neurotransmitter and hormone receptors and ion channels. The membraneembedded ...
Single-Channel Kinetic Analysis for Activation and Desensitization of Homomeric 5-HT3A Receptors
(Cell Press, 2009-09)
The 5-HT3A receptor is a member of the Cys-loop family of ligand-gated ion channels. To perform kinetic analysis, we mutated the 5-HT3A subunit to obtain a high-conductance form so that single-channel currents can be ...