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TNF-alpha Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons
(2018)
The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH oxidase has been documented during inflammatory pain. However, the molecular mechanism involved in their activation is not fully understood. ...
c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice
(2011)
The c-Abl tyrosine kinase is an important link in signal transduction pathways that promote cytoskeletal rearrangement and apoptotic signalling. We have previously shown that amyloid-beta-peptide (A beta) activates c-Abl. ...
Pro-inflammatory cytokines and gelatinases in climatic droplet keratopathy
(Association for Research in Vision and Ophthalmology, 2012-06)
PURPOSE. Climatic droplet keratopathy (CDK) is a degenerative disease of the cornea with possible involvement from matrix metalloproteinases (MMPs). Therefore, the authors investigated histologic distribution, levels, and ...
Association between the expression of amphetamine-induced behavioral sensitization and Cdk5/p35 activity in dorsal striatum
(American Psychological Association, 2016-02)
Sensitization to psychostimulants is strongly influenced by the environmental context in which the drug is administered and little is known about the molecular mechanisms that regulate this process. Chronic treatment with ...
Participación De P35, Activador Neuroespecífico De CDK5, En La Muerte Celular Inducida Por El Péptido Beta Amieloide. Aspectos Celulares Y MolecularesParticipation Of P35, Neurospecific Activator Of CDK5, In Celular Death Induced By Amyeloid BetaParticipación de p35, activador neuroespecífico de cdk5, en la muerte celular inducida por el péptido beta amieloide. Aspectos celulares y molecularesparticipatión of p35, neurospecific activator of cdk5, in celular death induced by amyeloid beta
(2006)
La enfermedad de Alzheimer (EA) es un desorden neurodegenerativo que se caracteriza por dos tipos de agregados proteicos: extracelulares (placas seniles) e intracelulares (ovillos neurofibrilares, ONF). Los ONF están ...
Modificaciones post traduccionales de CDK5 y sus efectos en la viabilidad neuronal
(Universisdad de Chile, 2009)
La quinasa dependientes de ciclina 5 (Cdk5) esta involucrada en proceso de migración, crecimiento neurótico y diferenciación neuronal. La actividad de Cdk5 en el sistema nervioso esta regulado por la interacción con sus ...
Genetic Background and Climatic Droplet Keratopathy Incidence in a Mapuche Population from Argentina
(Public Library Science, 2013-09)
Purpose To determine whether the incidence of and susceptibility to climatic droplet keratopathy (CDK), an acquired, often bilateral degenerative corneal disease, is influenced by the genetic background of the individuals ...
Cdk5 regulates Rap1 activity
(2013)
Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such ...
Cdk5 regulates Rap1 activity
(2013)
Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such ...
Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide A beta(25-35): Involvement of Lipid Rafts
(IOS PRESS, 2009)
Alzheimer’s disease (AD) is characterized by the accumulation of protein filaments, namely extracellular amyloid-β
(Aβ) fibrils and intracellular neurofibrillary tangles, which are composed of aggregated hyperphosphorylated ...