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A combined theoretical and spectroscopic study of 4,6-di-O-acetyl-2,3-dideoxy-d-erythro-hex-2-enopyranosyl sulfamide: a novel glycosyl carbonic anhydrase IX inhibitor
(Elsevier, 2011-02)
The novel 4,6-di-O-acetyl-2,3-dideoxy-D-erythro-hex-2-enopyranosyl sulfamide, which exhibits selectivity for inhibiting isoform IX of carbonic anhydrase as overexpressed in many tumors, has been investigated from a combined ...
Evolutionary Analysis of -Carbonic Anhydrase and Structurally Related Proteins
(Academic Press Inc Elsevier Science, 2000-12)
We studied the evolutionary relationships between γ-carbonic anhydrase (γ-CA) and a very diverse group of proteins that share the sequence motif characteristic of the left-handed parallel β-helix (LβH) fold. This sequence ...
Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV
(Pergamon-Elsevier Science Ltd, 2013-03)
A set of sulfamides and sulfamates were synthesized and tested against several isoforms of carbonic anhydrase: CA I, CA II, CA VII, CA XII and CA XIV. The biological assays showed a broad range of inhibitory activity, and ...
A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors
(Taylor & Francis Ltd, 2019-09)
Trypanosoma cruzi carbonic anhydrase (TcCA) has recently emerged as an interesting target for the design of new compounds to treat Chagas disease. In this study we report the results of a structure-based virtual screening ...
Carbonic anhydrase XIV in the normal and hypertrophic myocardium
(Academic Press Ltd - Elsevier Science Ltd, 2011-12)
Two AE3 transcripts, full-length (AE3fl) and cardiac (AE3c) are expressed in the heart. AE3 catalyzes electroneutral Cl−/HCO3− exchange across cardiomyocyte sarcolemma. AE proteins associate with carbonic anhydrases (CA), ...
Carbonic anhydrase inhibitors reduce cardiac dysfunction after sustained coronary artery ligation in rats
(Elsevier Science Inc, 2016-11)
Background Two potent carbonic anhydrase (CA) inhibitors with widely differing membrane permeability, poorly diffusible benzolamide (BZ), and highly diffusible ethoxzolamide (ETZ) were assessed to determine whether they ...
Inhibition of carbonic anhydrase prevents the Na /H exchanger 1-dependent slow force response to rat myocardial stretch
(American Physiological Society, 2013-07)
Myocardial stretch is an established signal that leads to hypertrophy. Myocardial stretch induces a first immediate force increase followed by a slow force response (SFR), which is a consequence of an increased Ca2+ transient ...
Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII: The out of the active site pocket for the design of selective inhibitors?
(Taylor & Francis Ltd, 2021-10-04)
New C-glycosides and a,b-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated. The inhibition profile of ...
Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors
(American Chemical Society, 2020-05)
The synthesis of selective inhibitors of human carbonic anhydrases (hCAs) is of paramount importance to avoid side effects derived from undesired interactions with isoforms not involved in the targeted pathology, and this ...