Buscar
Mostrando ítems 31-40 de 1087
Papel de las enzimas citocromo p450 en el metabolismo de fármacos antineoplásicos: Situación actual y perspectivas terapéuticas
(Sociedad Médica de Santiago, 2008)
Cytochrome P450 expression in mouse brain: specific isoenzymes involved in Phase I metabolizing system of porphyrinogenic agents in both microsomes and mitochondria
(Natl Research Council Canada-n R C Research Press, 2015-02)
Brain cytochrome P450 (CYP) metabolizes a variety of drugs to produce their pharmacological effects within the brain. We have previously observed that porphyrinogenic agents altered CYP levels in brain. The aim of this ...
Cytochrome P450 2C19 poor metabolizer phenotype in treatment resistant depression: Treatment and diagnostic implications
(Frontiers Media, 2019)
Background: Pharmacogenomic testing, specifically for pharmacokinetic (PK) and pharmacodynamic (PD) genetic variation, may contribute to a better understanding of baseline genetic differences in patients seeking treatment ...
Mechanisms underlying the inhibition of the cytochrome P450 system by copper ions
(WILEY, 2009)
Copper toxicity has been associated to the capacity of free copper ions to catalyze the production of superoxide anion and hydroxyl radical, reactive species that modify the structure and/or function of biomolecules. In ...
Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism
(ELSEVIER IRELAND LTD, 2010)
Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endogenous circulating levels of this hormone. Hepatic endoplasmic reticulum contains the cytochrome P450 (CYP450) system, ...
Microsomal and peroxisomal fatty acid oxidation in bile duct ligated rats: A comparative study between liver and kidney
(1997)
1. Microsomal cytochrome P-450 and peroxisomal fatty acid oxidation was studied in the kidney of rats 7 days after bile duct ligation (BDL) and a comparative study between kidney and liver was done. 2. Only in the liver ...
Microsomal and peroxisomal fatty acid oxidation in liver of rats with bile duct ligation and two-thirds hepatectomy
(1997)
Microsomal cytochrome P450 and peroxisomal activity were studied in liver of rats 7 days after two-thirds hepatectomy or bile duct ligation (BDL). Both surgical models decreased the hepatic microsomal cytochrome P450 ...
Kidney drug metabolizing activities in streptozotocin diabetic rats
(1995)
1. 1. Streptozotocin-induced diabetes produced significant changes on the drug metabolizing enzyme machinery of rat kidney microsomes. 2. 2. It reduced the cytochrome P-450 content by 30%, this effect being reversed by ...