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Cytotoxicity of prodigiosin and benznidazole on V79 cells
(Elsevier Ireland LtdClareIrlanda, 2000)
Combined therapy with Benznidazole and repurposed drugs Clofazimine and Benidipine for chronic Chagas disease
(Elsevier France-editions Scientifiques Medicales Elsevier, 2019-10)
Current treatment for Chagas disease is limited to Benznidazole andNifurtimox which present side effects and limited efficacy at the chronicstage of disease. This underscores the need for novel therapeuticapproaches ...
Correction to: Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): study protocol for a randomised controlled trial (vol 20, 431, 2019)
Background: Either benznidazole (BZN) or nifurtimox (NFX) is recommended as equivalent to treat Trypanosoma cruzi infection. Nonetheless, supportive data from randomised trials is limited to individuals treated with BZN ...
Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): Study protocol for a randomised controlled trial
Background: Either benznidazole (BZN) or nifurtimox (NFX) is recommended as equivalent to treat Trypanosoma cruzi infection. Nonetheless, supportive data from randomised trials is limited to individuals treated with BZN ...
Efecto tripanomicida de nuevos derivados de 1-{(5-r1 tiofen)metilen} -2- (o-;p-r2) fenil hidrazona sobre estadios de Trypanosoma cruzi presentes en el huésped vertebrado
(10/08/2009)
ABSTRACT: Trypanosoma cruzi is a protozoan parasite that causes Chagas disease. The drugs most frequently used for the treatment are the nitroheterocyclic compounds: nitrofuran (nifurtimox) and nitroimidazole derivative ...
Efecto de derivados de 3-metilquinoxalina-7-carboxilato 1,4-d-N-óxido sobre la expresión de los genes SOD y TR en epimastigotes de Trypanosoma cruzi
(2018-04-09)
RESUMEN: Trypanosoma cruzi es el agente etiológico de la enfermedad de Chagas. Se estima
que en el mundo hay entre 6 y 7 millones de personas infectadas por T. cruzi. Los dos
únicos fármacos utilizados para tratar esta ...
Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain
(Elsevier Science, 2016-04)
Chagas disease, caused by Trypanosoma cruzi, is the main cause of dilated cardiomyopathy in the Americas. Antiparasitic treatment mostly relies on benznidazole (Bzl) due to Nifurtimox shortage or unavailability. Both induce ...
Obtenção de nanoanticorpos e síntese de compostos antichagásicos derivados de tiossemicarbazona
(Universidade Estadual Paulista (Unesp), 2009-08-25)
A doença de Chagas ou Tripanossomíase americana é ainda um dos maiores problemas endêmicos na América Latina desde sua descoberta 100 anos atrás. Em 2006, havia aproximadamente 7,6 milhões de casos de infecção por Trypanosoma ...