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Imunização de camundongos obesos com o gene da ASP- 2 de Trypanosoma cruzi
(Universidade Federal de São Paulo (UNIFESP), 2019-05-27)
Immunization of obese mice with ASP-2 gene of the Trypanosoma cruzi Chagas disease is an illness caused by the intracellular protozoan Trypanosoma cruzi and the specific immune response mediated by CD8+ T cells is critical ...
Competitive glucose metabolism as a target to boost bladder cancer immunotherapy
(Nature Publishing Group, 2020-01-17)
Bladder cancer - the tenth most frequent cancer worldwide - has a heterogeneous natural history and clinical behaviour. The predominant histological subtype, urothelial bladder carcinoma, is characterized by high recurrence ...
Comparison of homologous and heterologous prime-boost immunizations combining MVA-vectored and plant-derived VP2 as a strategy against IBDV
(Elsevier, 2017-01)
Different immunogens such as subunit, DNA or live viral-vectored vaccines against Infectious Bursal Disease virus (IBDV) have been evaluated in the last years. However, the heterologous prime-boost approach using recombinant ...
Baculovirus capsid display in vaccination schemes: effect of a previous immunity against the vector on the cytotoxic response to delivered antigens
(Springer, 2018-12)
The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, although it also has been used as display vector for vaccine development. In this ...
Histamine in cancer immunology and immunotherapy. Current status and new perspectives
(John Wiley & Sons Inc., 2021-10)
Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. ...
Imunogenicidade de diferentes candidatos e estratégias vacinais para os vírus Zika e Chikungunya
(Universidade Federal de São Paulo (UNIFESP), 2021)
Arbovirus infections such as those caused by Zika virus (ZIKV) and Chikungunya virus (CHIKV) are responsible for a large number of cases with considerable severity and morbidity. So far, there are no vaccines or specific ...
Baculovirus capsid display in vaccination schemes: effect of a previous immunity against the vector on the cytotoxic response to delivered antigens
(Springer, 2018-12)
The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, although it also has been used as display vector for vaccine development. In this ...