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Bcl-X-L inhibits Bax-induced alterations in mitochondrial respiration and calcium release
(Elsevier B.V., 2008-09-12)
Apoptosis is a natural cell elimination process involved in a number of physiological and pathological events. This process can be regulated by members of the Bcl-2 family. Bax, a pro-apoptotic member of this family, ...
Lysosomal and mitochondrial permeabilization mediates zinc(II) cationic phthalocyanine phototoxicity
(Elsevier, 2013-11)
In order to find a novel photosensitizer to be used in photodynamic therapy for cancer treatment, we have previously showed that the cationic zinc(II) phthalocyanine named Pc13, the sulfur-linked dye 2,9(10),16(17),23(24 ...
Beclin 1
(Michigan Publishing, 2012)
Beclin 1/ATG6/Vps30 (UniProtKB/Swiss-Prot Q14457) is a 450 amino-acids length protein, with three domains; BH3 (aminoacid 114 to 123), Coiled Coil domain (CCD; aminoacid 144 to 269) and the Evolutionarily Conserved Domain ...
A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production
(Springer, 2013-06-01)
In cancer-treatment, potentially therapeutic drugs trigger their effects through apoptotic mechanisms. Generally, cell response is manifested by Bcl-2 family protein regulation, the impairment of mitochondrial functions, ...
BCL-2 family: integrating stress responses at the ER to control cell demise
(Nature Publishing Group, 2017)
In the last decade, the endoplasmic reticulum (ER) has emerged as a central organelle regulating the core mitochondrial apoptosis pathway. At the ER membrane, a variety of stress signals are integrated toward determining ...
High Bcl-2/Bax ratio in Walker tumor cells protects mitochondria but does not prevent H2O2-induced apoptosis via calcineurin pathways
(Springer/plenum PublishersNew YorkEUA, 2007)
The ovarian germinal reserve and apoptosis-related proteins in the infant and adolescent human ovary
(BioMed Central, 2019-03-11)
Background: Normal pubertal ovary displays all stages of follicular development and a biased BAX/BCL2 protein ratio in favor of pro-apoptotic BAX protein comparable to the adult ovary. However, adolescents suffering malignant ...