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Desmopressin in canine mammary carcinoma: Comments on the importance of the administration route
(Wiley Blackwell Publishing, Inc, 2021-09)
Several years ago, we proposed the haemostatic peptide desmopressin (1-desamino-8-d-arginine vasopressin; dDAVP) as a potential anti-metastatic agent to be used during surgical excision of locally advanced tumours. A ...
Efeitos de uma desintegrina RGD recombinante de Rhinocerophis alternatus (Bothrops alternatus) na migração de células normais e tumorais
(Universidade Federal de São CarlosBRUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF, 2011-08-03)
Cell migration, invasion of the surrounding tissues, blood vessels and proliferation are cellular processes involved in metastases. These events are mediated by integrins, adhesion receptors present on cell surfaces and ...
Ternary copper(II) complex of 5-hydroxytryptophan and 1,10-phenanthroline with several pharmacological properties and an adequate safety profile
(Elsevier Science Inc, 2019-12)
We report the synthesis and biological evaluation of a ternary copper complex, [Cu(5HTP)(phen)(H2O)](NO3).2H2O, with the antioxidant agent 5-hydroxytryptophan (5-HTP) and phenanthroline (phen, added to improve its lipophilicity ...
In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells
(Royal Society of Chemistry, 2020-10-14)
The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in ...
Nanoformulação do [10]-Gingerol em células de câncer de mama triplo negativo
(Universidade Federal de São CarlosUFSCarCâmpus São CarlosBiotecnologia - Biotec-Ar, 2020-10-08)
Breast cancer is the neoplasm that most affects women worldwide and can be classified into different types. Among them, triple negative breast cancer (TN) is characterized by not having hormone receptors, nor receptors for ...
O efeito da desintegrina DisBa-01 e do silenciamento da integrina avB3 e na interação de células tumorais e endoteliais in vitro
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEv, 2013-02-27)
Metastasis depends on several physiological processes such as cell adhesion, transendothelial cell migration and proliferation. These events are mediated mostly by integrins, which are adhesion receptors present on cell ...
Effects of melatonin on HIF-1α and VEGF expression and on the invasive properties of hepatocarcinoma cells
(2016-07-01)
Liver cancer is the sixth most commonly occurring cancer globally, and the main histological type is hepatocellular carcinoma. This type of neoplasia has a poor prognosis due to a high rate of recurrence and intrahepatic ...
Chalcone derivatives 4′-amino-1-naphthyl-chalcone (D14) and 4′-amino-4-methyl-1-naphthyl-chalcone (D15) suppress migration and invasion of osteosarcoma cells mediated by p53 regulating emt-related genes
(2018-09-19)
Osteosarcoma (OS) is a primary malignant bone tumor that mainly affects children, adolescents, and young adults. The inhibition of metastasis is a main strategy of OS therapy since the development of metastatic disease due ...
Heterobimetallic Ru(ii)/Fe(ii) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets
(Royal Soc Chemistry, 2020-04-01)
Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(ii) complexes attractive for the development of new chemotherapeutic agents for cancer treatment. In this study, cytotoxic ...
Lupane triterpenoids and new derivatives as antiproliferative agents against prostate cancer cells
(Int Inst Anticancer Research, 2019-05)
Background/Aim: This study examined the potential role of natural triterpenoids lupeol, calenduladiol and heliantriol B2, and a set of 19 derivatives, as antiproliferative and antimetastatic agents against prostate cancer ...