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5alpha-reductase 2 inhibition impairs brain defeminization of male rats: Reproductive aspects
(Elsevier B.V., 2005-09-01)
The present study was carried out to determine whether 5alpha-reductase 2 (5alpha-R2) metabolic pathway plays a key role in brain sexual differentiation. The inhibition of 5alpha-R2 by finasteride (20 mg/kg/day) from ...
Enhanced proinflammatory cytokine response to bacterial lipopolysaccharide in the adult male rat after either neonatal or prepubertal ablation of biological testosterone activity
(Karger, 2011-06)
A sex steroid-dependent modulation of the immune function in mammals is accepted, and evidence suggests that while estrogens enhance, androgens inhibit the immune response. The aim of this study was to explore in the adult ...
46,XY DSD due to impaired androgen production
(Elsevier, 2010-04)
Disorders of androgen production can occur in all steps of testosterone biosynthesis and secretion carried out by the foetal Leydig cells as well as in the conversion of testosterone into dihydrotestosterone (DHT). The ...
Study of some aryl-propionamide SARMs metabolism in food producing animals. Highlighting biomarkers of exposure and effects for control purposes.
(2020-06-25)
Compounds with anabolic properties have recently emerged: specific androgen receptor modulators (SARMs), currently being developed for the treatment of muscle-loss diseases. For example, commercially available Ostarine ...
46,XY DSD due to impaired androgen production
(ELSEVIER SCI LTD, 2010)
Disorders of androgen production can occur in all steps of testosterone biosynthesis and secretion carried out by the foetal Leydig cells as well as in the conversion of testosterone into dihydrotestosterone (DHT). The ...
Neuroprotective Effects of Testosterone in Male Wobbler Mouse, a Model of Amyotrophic Lateral Sclerosis
(Humana Press, 2021-01)
Patients suffering of amyotrophic lateral sclerosis (ALS) present motoneuron degeneration leading to muscle atrophy, dysphagia, and dysarthria. The Wobbler mouse, an animal model of ALS, shows a selective loss of motoneurons, ...
Short social interactions in male Japanese Quail fail to influence temporal dynamics of testicular and adrenocortical activities irrespective of photoperiodic reproductive status
(Wiley Blackwell Publishing, Inc, 2017-01)
This study evaluates whether short daily male conspecific visits influence the dynamics of endocrine testicular and adrenal photo-responsiveness. A group of male Japanese Quail was exposed to short photoperiods and another ...
Asynchronous breeding in red brocket deer (Mazama americana): seasonal changes in male reproductive characteristics, seminal parameters, androgen levels, and antler cycle
(2020-06-01)
The red brocket deer is the largest species in the genus Mazama and one of the most abundant and widely distributed cervid in the Neotropics. Yet it has been classified as data deficient by the IUCN, and the limited knowledge ...
Temporal dynamic of adrenocortical and gonadal photo-responsiveness in male Japanese quail exposed to short days
(Elsevier Inc, 2014-07)
The study evaluated whether different short-term endocrine testicular and adrenocortical responses to short photoperiod exposure can persist over time and particularly when birds exhibit spontaneous cloacal gland recovery. ...