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Androgen regulation of host defenses and response to inflammatory stimuli in the prostate gland
(Academic Press Ltd - Elsevier Science Ltd, 2017-11)
The prostate gland is a strictly androgen-dependent organ which is also the main target of infectious and inflammatory diseases in the male reproductive tract. Host defenses and immunity of the gland have unique features ...
Neonatal exposure to estradiol valerate reprograms the rat ovary androgen receptor and anti-Müllerian hormone to a polycystic ovary phenotype
(Elsevier INC, 2018)
To understand the impact of exposure to steroids in the early step of ovary development(a stage occurring
in uterus in humans), we studied neonatal exposure to estradiol valerate (EV) in rats regarding polycystic
ovary ...
Neonatal exposure to estradiol valerate reprograms the rat ovary androgen receptor and anti-Müllerian hormone to a polycystic ovary phenotype
(Elsevier Inc., 2018)
© 2017 Elsevier Inc. To understand the impact of exposure to steroids in the early step of ovary development (a stage occurring in uterus in humans), we studied neonatal exposure to estradiol valerate (EV) in rats regarding ...
Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators
(Cell Press, 2018-01-02)
The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The ...
Effects of melatonin and gonadal androgens on cell proliferation in the pituitary of viscachas (Lagostomus maximus maximus)
(Wiley Blackwell Publishing, Inc, 2016-10)
Objectives: Melatonin and androgens are involved in the regulation of cell proliferation. However, effects of these hormones on pituitary pars distalis (PD) of male viscachas is not fully understood. In the present study, ...
Prenatal androgen exposure affects ovarian lipid metabolism and steroid biosynthesis in rats
(BioScientifica, 2020-09)
Prenatal androgen exposure affects reproductive functions and has been proposed as an underlying cause of polycystic ovary syndrome (PCOS). In this study, we aimed to investigate the impact of prenatal androgen exposure ...
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
(Academic Press Inc Elsevier Science, 2013-10-01)
Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation ...
Role of testosterone and androgen receptor in periodontal disease progression in female rats
(2020-04-01)
Background: Sex hormone therapy has strict recommendations in the treatment of postmenopausal symptoms, in which testosterone (TES) replacement may play a potential role. However, it remains unclear whether TES affects the ...
P-Glycoprotein and Androgen Receptor Expression Reveals Independence of Canine Prostate Cancer from Androgen Hormone Stimulation
(2022-02-01)
Canine prostate cancer (PC) is an aggressive disease, and dogs can be considered comparative models for human PC. In recent years, canine PC has been shown to resemble human castrate-resistant prostate cancer. The influx ...
Effect of glucocorticoids on androgen biosynthesis in the testes of the toad Rhinella arenarum (Amphibia, Anura)
(John Wiley & Sons Inc, 2018-12)
In rat Leydig cells, glucocorticoids (GCs) inhibit testosterone production through the interaction with the glucocorticoid receptor (GR). However, the sensitivity of those cells to GCs is regulated by the enzyme ...