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Mostrando ítems 31-40 de 47
Caracterização de modelos de experimentação baseados na Doença de Alzheimer em zebrafish
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
New animal models for neurodegenerative diseases study are necessary for the knowledge of molecular mechanisms and behavioral patterns involved on the progression of dementias as Alzheimer’s Disease (AD) as well as for new ...
Caracterização de modelos de experimentação baseados na Doença de Alzheimer em zebrafish
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
New animal models for neurodegenerative diseases study are necessary for the knowledge of molecular mechanisms and behavioral patterns involved on the progression of dementias as Alzheimer’s Disease (AD) as well as for new ...
Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts
(Frontiers Media S.A., 2019-07-18)
Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), ...
A Desintegrina e Metaloproteinase 10 (ADAM10) como biomarcadora para a doença de Alzheimer: uma revisão sistemática
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Gerontologia - PPGGeroCâmpus São Carlos, 2022-08-08)
Introduction: Studies have shown that Disintegrin and Metalloproteinase 10 (ADAM10) is the
main α-secretase in the non-amyloidogenic cleavage of amyloid precursor protein (APP). ADAM10
prevents the production of β-amyloid ...
Desenvolvimento de um imunossensor descartável para o diagnóstico precoce da doença de Alzheimer
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2016-02-23)
The objective of this project is the developing of an immunosensor for detection of
a protein biomarker contained in peripheral blood, in this case the ADAM10, that
belong to the family of ADAM (A disintegrin and ...
Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease
(Feinstein Institute for Medical Research, 2008-03)
Presenilin (PS) mutations enhance the production of the Abeta42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Abeta42 species is preferentially produced has not been elucidated, ...
Nanopartículas plasmónicas para la detección de agregados del péptido β-amiloide mediante fluorescencia aumentada por superficie
(Universidad de Chile, 2020)
Una de las hipótesis más aceptada para la etiología de la enfermedad de Alzheimer (EA) es
la “hipótesis de la cascada amiloide”. Esta hipótesis se centra en la acumulación de
agregados tóxicos del péptido β-amiloide (Aβ), ...
Altered APP Processing in PDAPP (Val717 → Phe) Transgenic Mice Yields Extended-Length Aβ Peptides.
(American Chemical Society, 2005-10)
Central to the pathology of Alzheimer's disease (AD) is the profuse accumulation of amyloid-beta (Abeta) peptides in the brain of affected individuals, and several amyloid precursor protein (APP) transgenic (Tg) mice models ...
BACE1 RNAi restores the composition of phosphatidylethanolamine-derivates related to memory improvement in aged 3xTg-AD mice
(Frontiers Research FoundationGrupo de Neurociencias de AntioquiaSuiza, 2017)