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Hemichannels Are Required for Amyloid beta-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice
(2015)
Mast cells (MCs) store an array of proinflammatory mediators in secretory granules that are rapidly released upon activation by diverse conditions including amyloid beta (A beta) peptides. In the present work, we found a ...
Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons
(2012)
Two major lesions are pathological hallmarks in Alzheimer's disease (AD): the presence of neurofibrillary tangles formed by intracellular aggregates of the hyperphosphorylated form of the cytoskeletal tau protein, and of ...
Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets
(Elsevier Science, 2011)
Amyloid-β (Aβ) peptides are intimately involved in the inflammatory pathology of atherosclerotic vascular disease (AVD) and Alzheimer's disease (AD). Although substantial amounts of these peptides are produced in the ...
Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures
(Oxford University Press, 2020-08-28)
A QM/MM study of the molecular recognition site of bapineuzumab toward the amyloid-β peptide isoforms
(Taylor & Francis Ltd, 2016-02)
The molecular mechanism of recognition of amyloid-beta (Aβ) peptide isoforms by bapineuzumab was studied using a quantum mechanics and molecular mechanics (QM/MM) method. In this work, geometric optimisations were performed ...
Functionalization of stable fluorescent nanodiamonds towards reliable detection of biomarkers for Alzheimer's disease
(BMC, 2018)
Background: Stable and non-toxic fluorescent markers are gaining attention in molecular diagnostics as powerful tools for enabling long and reliable biological studies. Such markers should not only have a long half-life ...
In silico evidence of direct interaction between statins and β-amyloid
(Wiley-Liss Inc., 2019)
Peptide multifunctionalized gold nanorods decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease
(Elsevier Inc., 2017)
© 2017 Elsevier Inc. The properties of nanometric materials make nanotechnology a promising platform for tackling problems of contemporary medicine. In this work, gold nanorods were synthetized and stabilized with polyethylene ...