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Hemichannels Are Required for Amyloid beta-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice
(2015)
Mast cells (MCs) store an array of proinflammatory mediators in secretory granules that are rapidly released upon activation by diverse conditions including amyloid beta (A beta) peptides. In the present work, we found a ...
Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
(Springer, 2016)
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats
(Frontiers Media Sa, 2018)
The cause of Alzheimer’s disease (AD) remains uncertain. The accumulation of amyloid peptides (Aβ) is the main pathophysiological hallmark of the disease. Spatial deficit is an important initial sign of AD, while other ...
Functionalization of stable fluorescent nanodiamonds towards reliable detection of biomarkers for Alzheimer's disease
(BMC, 2018)
Background: Stable and non-toxic fluorescent markers are gaining attention in molecular diagnostics as powerful tools for enabling long and reliable biological studies. Such markers should not only have a long half-life ...
Establishment of Constraints on Amyloid Formation Imposed by Steric Exclusion of Globular Domains
(Academic Press Ltd - Elsevier Science Ltd, 2018-10)
In many disease-related and functional amyloids, the amyloid-forming regions of proteins are flanked by globular domains. When located in close vicinity of the amyloid regions along the chain, the globular domains can ...
Effects of a disulfide bridge prior to amyloid formation of the ABRI peptide
(Royal Society of ChemistryGrupo de Biofísica - UdeAReino Unido, 2022)