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Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
(Elsevier, 2013-02)
Aldosterone modulates the activity of the epithelial sodium channel (ENaC) through changes in its trafficking, membrane expression and open probability. Plasma levels of aldosterone are decreased in preeclampsia. Herein ...
Cation permeability of a cloned rat epithelial amiloride-sensitive Na+ channel
(1997)
1. Conductance of heterotrimeric rat epithelial Na+ channels (α,β,γ-rENaCs) for Li+ and Na+ in planar lipid bilayers was a non-linear function of ion concentration, with a maximum of 30.4 ± 2.9 pS and 18.5 ± 1.9 pS at 1 M ...
The multimeric structure of polycystin-2 (TRPP2): Structural - Functional correlates of homo- and hetero-multimers with TRPC1
(Oxford University Press, 2009-04)
Polycystin-2 (PC2, TRPP2), the gene product of PKD2, whose mutations cause autosomal dominant polycystic kidney disease (ADPKD), belongs to the superfamily of TRP channels. PC2 is a non-selective cation channel, with ...
Effectiveness of low-dose diuretics for blood pressure reduction to optimal values in prehypertension: A randomizedclinical trial
(2018-04-01)
Background: To determine the effectiveness of low-dose diuretic therapy to achieve an optimal level of blood pressure (BP) in adults with prehypertension. Methods: The PREVER-prevention trial was a randomized, parallel, ...
Uso do eletrodo de diamante dopado com boro acoplado a um sistema BIA para determinação simultânea de princípios ativos em medicamentos
(Universidade Federal de UberlândiaBRPrograma de Pós-graduação Multi-Institucional em Quimica (UFG - UFMS - UFU)Ciências Exatas e da TerraUFU, 2016)
Inhibition of epithelial sodium channel (enac) with amilorideimproves endothelium-derived vasodilation in angiotensin ii(aii)-treated rats
(FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, 2011)
ENaC is expressed in the endothelium, and may affect vascular tone, since inhibitors of the mineralocorticoid receptor, ENaC main regulator, produce favorable effects in different types of hypertension, independently of ...
The neuropeptide RhoprCCHamide2 inhibits serotonin-stimulated transcellular Na+ transport across the anterior midgut of the vector of Chagas disease, Rhodnius prolixus
(Company of Biologists, 2021-04)
Rhodnius prolixus is a blood-feeding insect vector of Trypanosoma cruzi, a protozoan parasite that causes Chagas disease. During each blood meal, the animals ingest large volumes of blood, that may be up to 12 times the ...
Cell Migration in BeWo Cells and the Role of Epithelial Sodium Channels
(Springer, 2009-11)
Cell migration/proliferation processes associated with wound healing were measured in BeWo cells at 6 h, when mitosis is still scarce. Cells were cultured in medium with 1% fetal bovine serum to minimize proliferation. ...