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The herbicide glyphosate is a weak inhibitor of acetylcholinesterase in rats
(Elsevier Science, 2016-07)
The current work evaluated the inhibitory potency of the herbicide glyphosate (GLP) on acetylcholinesterase (AChE) activity in male and female rat tissues. The AChE activity in brain was higher (p < 0.05) than those observed ...
Resistance to inhibitors of cholinesterase 3 (Ric-3) expression promotes selective protein associations with the human α7-nicotinic acetylcholine receptor interactome
(Public Library of Science, 2015)
Abstract: The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs ...
Resistance to inhibitors of cholinesterase 3 (Ric-3) expression promotes selective protein associations with the human α7-nicotinic acetylcholine receptor interactome
(Public Library of Science, 2015-08)
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs need to be ...
Synthesis and cholinesterase inhibition of cativic acid derivatives
(Elsevier, 2014-06)
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with memory impairment and cognitive deficit. Most of the drugs currently available for the treatment of AD are acetylcholinesterase (AChE) inhibitors. ...
Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database
(2021)
Alzheimer's disease is the most common form of dementia, representing 60-70% of dementia cases. The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in acetylcholine and plays an important role in the termination ...
Síntesis y relación estructura-actividad de derivados Arílicos como posibles inhibidores de Colinesterasas
(2008-11-27)
RESUMEN:
La enfermedad de Alzheimer (EA) es un síndrome demencial caracterizado por disminución de acetilcolina (ACh) en el hipocamco y la corteza cerebral. Lo que ha inducido al desarrollo de inhibidores de acetilcolinesterasa ...
Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors
(Nature Publishing Group, 2005-06-27)
1 Effects of derivatives of coclaurine (C), which mimic the ‘eastern’ or the nonquaternary halves of
the alkaloids tetrandrine or d-tubocurarine, respectively, both of which are inhibitors of nicotinic
acetylcholine ...
Molecular Docking and Molecular Dynamic Studies of Semi-Synthetic Piperidine Alkaloids as Acetylcholinesterase Inhibitors
(Soc Brasileira Quimica, 2014)
Planejamento racional por modelagem molecular, síntese e caracterização de glicosídeos com atividade inibitória potencial da acetilcolinesterase
(Universidade Federal de Minas GeraisUFMG, 2012-02-29)
Acetylcholinesterase (AChE) is the enzyme that catalyses the hydrolysis of the neurotransmitter acetylcholine, terminating synaptic cholinergic transmission. The use of AChE inhibitors have been associated with the improvement ...